GenomeNet

Database: UniProt
Entry: E1BQT2_CHICK
LinkDB: E1BQT2_CHICK
Original site: E1BQT2_CHICK 
ID   E1BQT2_CHICK            Unreviewed;      2006 AA.
AC   E1BQT2;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 3.
DT   27-SEP-2017, entry version 60.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN2A {ECO:0000313|Ensembl:ENSGALP00000017912};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000017912, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000017912, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017912,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000017912}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000017912};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000017912}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AADN04000247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001280210.1; NM_001293281.1.
DR   RefSeq; XP_015145119.1; XM_015289633.1.
DR   UniGene; Gga.14586; -.
DR   UniGene; Gga.54858; -.
DR   STRING; 9031.ENSGALP00000017912; -.
DR   PaxDb; E1BQT2; -.
DR   Ensembl; ENSGALT00000017933; ENSGALP00000017912; ENSGALG00000011009.
DR   GeneID; 395945; -.
DR   CTD; 6326; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; E1BQT2; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   PRO; PR:E1BQT2; -.
DR   Proteomes; UP000000539; Chromosome 7.
DR   Bgee; ENSGALG00000011009; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    401    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    752    776       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    788    809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    871    899       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    961    984       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1249   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1352       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1450   1474       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1563   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1678       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1754   1777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    435       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    710       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      761    989       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      998   1204       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1208   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1532   1787       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      425    470       {ECO:0000256|SAM:Coils}.
FT   COILED      497    531       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2006 AA;  228288 MW;  4E261C391BAF2596 CRC64;
     MAQSVLVPPG PDSFRYFTRE SLAAIEQRIN EEKAKKSKQE RKDDDDEDGP KPNSDLEAGK
     TLPFIYGDIP PGMVSEPLED LDPYYINKKT FIVLNKGKAI FRFSATSALY MLTPFNPLRK
     IAIKILVHSL FSMLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC
     LEDFTFLRDP WNWLDFTVIT FAYVTEFVDL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFET TVITYFNSSI
     GENGTFINTT MTIFNWDEYI EDENHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP
     NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI
     LAVVAMAYEE QNQATMEEAE QKEAEFQQML EQLKKQQEEA QAAAAAAAAD SRDYSGVGGI
     GGFSESSSEA SKLSSKSAKE RRNRRKKKKQ KEQAEGEKDE EEFRKSESED SIKRKGFRFS
     IEGNRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRTSLFSF RGRAKDVGSE NDFADDEHST
     FEDNESRRDS LFVPHRHGER RNSNISQASR SSRTVPPLPV NGKMHSTVDC NGVVSLVGGP
     PALTSPTGQL LPEGTTTETD LRKRRSSSYQ VPMDYLTDPS ARQRAMSIAS MLTNTMEELE
     ESRQKCPPCW YKFANTCLIW DCCTPWLKVK HIVNLIVMDP FVDLAITICI VLNTLFMAME
     HYPMTEQFSG VLSVGNLVFT GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG
     LANVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
     MQLFGKSYKE CVCKISSDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD CMEVAGQTMC
     LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE MNNLQIAVAR IQKGIDFVKR
     KVREFIQKAF VRKQKVLDEI KPLEDLNNKK DSCISNHTIV EIGKNLAYLK EGNGTTSGIG
     SSVEKYVVDE SDYMSFINNP SLTVTVPIAV GESDFENLNT EEFSSESDLE ESKEKLNASS
     SSEGSTVDIG LPPEGEQPEV EPEESLEPEA CFTEGCVRRF KCCQVSVEDG KGKIWWNLRK
     TCYKIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF TYIFILEMLL
     KWVAYGFQTY FTNAWCWLDF LIVDVSLVSL TANALGYSEL GAIKSLRTLR ALRPLRALSR
     FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYYCVNT TTDERFDISQ
     INNYSQCEEL IKNNETARWK NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVLD
     QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPANK FQGMVFDFVT KQAFDISIMI LICLNMVTMM VETDDQSEDM
     ENILYWINLV FIVLFTGEFV LKLISLRHYY FTIGWNIFDF VVVILSIVGM FLAEMIEKYF
     VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM
     SNFAYVKREV GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSGEP DCDPHKDHPG
     SSVKGDCGNP SVGIFFFVSY IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
     EVWEKFDPDA TQFIEFSKLS DFAASLDPPL LIAKPNKVQL IAMDLPMVSG DRIHCLDILF
     AFTKRVLGES GEMDALRIQM EDRFMAANPS KVSYEPITTT LKRKQEEVSA VVIQRAFRRH
     LLRQKVKKVS CIFNQDKGKD EDDLPMKEDM IMDKLNENST PEKTDMTPST TSPPSYDSVT
     KPDKDKYEKD KSEKEDKGKD SRESKK
//
DBGET integrated database retrieval system