GenomeNet

Database: UniProt
Entry: E1BSL8_CHICK
LinkDB: E1BSL8_CHICK
Original site: E1BSL8_CHICK 
ID   E1BSL8_CHICK            Unreviewed;      1738 AA.
AC   E1BSL8;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 3.
DT   25-OCT-2017, entry version 64.
DE   SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSGALP00000027197};
GN   Name=NALCN {ECO:0000313|Ensembl:ENSGALP00000027197};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000027197, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000027197, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000027197,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000027197}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000027197};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000027197}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AADN04000044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015130472.1; XM_015274986.1.
DR   UniGene; Gga.19117; -.
DR   STRING; 9031.ENSGALP00000027197; -.
DR   PaxDb; E1BSL8; -.
DR   PRIDE; E1BSL8; -.
DR   Ensembl; ENSGALT00000027248; ENSGALP00000027197; ENSGALG00000016868.
DR   GeneID; 418770; -.
DR   CTD; 259232; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; E1BSL8; -.
DR   OMA; MLGDSAM; -.
DR   OrthoDB; EOG091G00F9; -.
DR   PhylomeDB; E1BSL8; -.
DR   TreeFam; TF312843; -.
DR   Reactome; R-GGA-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000016868; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1017   1040       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1211   1231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1276   1294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1336   1358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1423   1447       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      384    603       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1162       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1209   1457       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      798    827       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1738 AA;  200246 MW;  AD3E454C3A71F498 CRC64;
     MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPKT
     FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV
     SLVLQVFEIA EIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFTYHCVTD DTQPGNVTWN NLAIPDTHCS RELEEGYQCP
     PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF
     YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ
     LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVAVDVIV AASNYYKGEN FKRQYDEFYL
     AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHIYPDLY HSQFTYFQVL
     RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
     PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLIL LSLFVAVILD
     NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE
     SFMKQFIDRQ QQDTSCLLRR LPSASSSSCD HSKRSAIEEN KYIDQKLRKS VFSIRARNLL
     EKETAINKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK
     SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV
     GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMIIVTICSC
     ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF
     IYLVSLIFLC WMPQNVPAKS GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV
     SILLLTLMLV FASFGVQLFA GKLAKCNDPH IISREDCHGI FRINVSVSKN LNLKLRPGEK
     KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV
     FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR
     AKMYDVTQHP FFKRTIAVLV LAQSVLLSVK WDAADPVTVP LATMSVVFTF IFVLEVTMKI
     IAMSPSGFWQ SRRNRYDLLV TSLGVIWVIL HFALLNAYTY MMGACVIVFR FFSICGKHVT
     LKMLLLTVVV SMYKSFFIIV GMFLLLLCYA FAGVVLFGTV KYGENINRHA NFSSAGKAIT
     VLFRIVTGED WNKIMHDCMV QPPFCTPDNS TYWKTDCGNY AGALMYFCSF YVIIAYIMLN
     LLVAIIVENF SLFYSTEEDQ LLSYNDLRHF QIIWNMVDDK REGVIPTFRV KFLLRLLRGR
     LEVDLDKDKL LFKHMCYEME RLHNGGDVTF HDVLSMLSYR SVDIRKSLQL EELLAREQLE
     YTIEEEVAKQ TIRMWLKKCL KRIRAKQQQS CSIIHSLRES QQQELSRFLN PPSIETTQPS
     EDMNAINQDN SAQPETSSQQ QLLSPTLSDR GGYRQDSADA GKPQWKIRPR CLPSSPKPRS
     HPGSSVNLRS GGCLTVKSVG CKMNPMSDAA SCGSEVKKWW TRQLTVESDE SGEDLLDI
//
DBGET integrated database retrieval system