ID E1BVI5_CHICK Unreviewed; 468 AA.
AC E1BVI5; F5ANP1;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=5-hydroxytryptamine receptor 2A {ECO:0000256|ARBA:ARBA00017579, ECO:0000256|RuleBase:RU368060};
DE Short=5-HT-2 {ECO:0000256|RuleBase:RU368060};
DE AltName: Full=Serotonin receptor 2A {ECO:0000256|ARBA:ARBA00032258, ECO:0000256|RuleBase:RU368060};
GN Name=HTR2A {ECO:0000313|EMBL:AEC53543.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AEC53543.1};
RN [1] {ECO:0000313|EMBL:AEC53543.1}
RP NUCLEOTIDE SEQUENCE.
RA Wong M.T., Kwok A.H.Y., Wang Y., Leung F.C.;
RT "Molecular Characterization of Chicken 5-Hydroxytryptamine (Serotonin)
RT Receptor 2A (HTR2A) Gene.";
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
CC (serotonin). {ECO:0000256|RuleBase:RU368060}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368060};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU368060}. Cell
CC projection, dendrite {ECO:0000256|ARBA:ARBA00004279,
CC ECO:0000256|RuleBase:RU368060}. Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489, ECO:0000256|RuleBase:RU368060}.
CC Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00004541,
CC ECO:0000256|RuleBase:RU368060}. Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004345, ECO:0000256|RuleBase:RU368060}.
CC Presynapse {ECO:0000256|RuleBase:RU368060}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; HQ438965; AEC53543.1; -; mRNA.
DR RefSeq; NP_001305349.1; NM_001318420.1.
DR AlphaFoldDB; E1BVI5; -.
DR STRING; 9031.ENSGALP00000027400; -.
DR PaxDb; 9031-ENSGALP00000027400; -.
DR GeneID; 428070; -.
DR KEGG; gga:428070; -.
DR CTD; 3356; -.
DR VEuPathDB; HostDB:geneid_428070; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_3_1; -.
DR InParanoid; E1BVI5; -.
DR OMA; VTIGIHH; -.
DR OrthoDB; 2880253at2759; -.
DR Reactome; R-GGA-390666; Serotonin receptors.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR Bgee; ENSGALG00000016992; Expressed in spleen and 7 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-UniRule.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR CDD; cd15304; 7tmA_5-HT2A; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000455; 5HT2A_rcpt.
DR InterPro; IPR002231; 5HT_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF30; 5-HYDROXYTRYPTAMINE RECEPTOR 2A; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00516; 5HT2ARECEPTR.
DR PRINTS; PR01101; 5HTRECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Cell membrane {ECO:0000256|RuleBase:RU368060};
KW Cell projection {ECO:0000256|RuleBase:RU368060};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|RuleBase:RU368060};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368060};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AEC53543.1};
KW Synapse {ECO:0000256|RuleBase:RU368060};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368060}.
FT TRANSMEM 74..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 109..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 148..169
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 190..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 321..345
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368060"
FT DOMAIN 89..377
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 468 AA; 52671 MW; 6B58125202DB8AAF CRC64;
MDTLCDEESS VNPTANPLIQ INHERRLYRN VYGPGEINVS HFCNLTADPE NLTNLSCESP
PCYSSLFQLS EKNWPALLTV IVIVLTIAGN ILVIMAVSLE KKLQNATNYF LMSLAIADML
LGFLVMPVSM LTILYGYKWP LPRKFCAIWI YLDVLFSTAS IMHLCAISLD RYIAIRNPIY
HSRFNSRTKA FAKIIAVWTI SVGISMPIPV FGLQNDCKVF KKGHCLLADE NFVLIGSFAA
FFIPLTIMVV TYFLTIRSLQ KEAMLCVNDI GPKTKFASFS FLPQSSLSSE KLFQRSLNRD
MGTSGRRTMQ SISNEQKASK VLGIVFFLFV VMWCPFFITN VMAVICKESC NEEVIGGLLN
IFVWIGYLSS AVNPLVYTLF NKTYRSAFSR YIQCRYKEEK KPFQLILVNT IPALAYNSSQ
LHLAQMKSLK KEAKLMSKDY SMVTIGIRHM DGTSKGSISP GNEKVSGV
//
