ID E1BWW3_CHICK Unreviewed; 1096 AA.
AC E1BWW3;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Structural maintenance of chromosomes 6 {ECO:0000313|Ensembl:ENSGALP00010003252.1};
GN Name=SMC6 {ECO:0000313|Ensembl:ENSGALP00010003252.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010003252.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010003252.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010003252.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
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DR RefSeq; NP_001308543.1; NM_001321614.1.
DR AlphaFoldDB; E1BWW3; -.
DR SMR; E1BWW3; -.
DR STRING; 9031.ENSGALP00000026518; -.
DR PaxDb; 9031-ENSGALP00000026518; -.
DR Ensembl; ENSGALT00010005414.1; ENSGALP00010003252.1; ENSGALG00010002372.1.
DR GeneID; 421950; -.
DR KEGG; gga:421950; -.
DR CTD; 79677; -.
DR VEuPathDB; HostDB:geneid_421950; -.
DR GeneTree; ENSGT00550000074816; -.
DR InParanoid; E1BWW3; -.
DR OMA; MCHDHFY; -.
DR Reactome; R-GGA-3108214; SUMOylation of DNA damage response and repair proteins.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000016467; Expressed in spermatid and 13 other cell types or tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0035061; C:interchromatin granule; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0000803; C:sex chromosome; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0000217; F:DNA secondary structure binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT DOMAIN 56..1067
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
SQ SEQUENCE 1096 AA; 127754 MW; 3C40601013B2955B CRC64;
MGKRKEESVS KLPSHKRQRQ EHTDEHSDES SEEENSQFSA DNSFSLTSTV GEAGIIESIQ
LKNFMCHSML GPFQFGSNLN FIIGNNGSGK SSVLTALIVG LGGKATATNR GSSLKMFVKS
GETSADISVT LQNQGRDAFK PELYGDSIIV NTHINLEGSR TYRLKSKSGA IISSKKEELL
GMLDHFNIQV ENPVSVLTQE MSKLFLQSKN EGDKYKFFMK ATQLEQMKED YSYIMKTKEN
TRLQIEQGVE RLKELKRIYC EEKERYESIE CVNEMQKHLE ELKHKMAWAV VAEMEREIQP
IREGIKAEEG NTEKFDQKLE ECQIKINEAE EQCKAIQEKL ITVNGEAEAL HAQCMSSKAE
VQTRRKAVNE AEVLYNRVRT ELKRLAKDDE QLRNRIEEMK KRAYQASEPE RLEKQRKITQ
LKEKLKALHD EEIMMGQQMD QFQQAIYKHK EEFAKLKRED SDVRQDLDGK QKHLRELRDS
KTNAFKRFGQ HMPSLLEEVE KAYRQGQFKY KPVGPLGAFI HPKDPELSLA IEACLKTLVQ
AFCCDNHSDE RILQQLMSKY YPRGARPSII VNKFHDKIYD VRHSGVHHPE FPSVLTALEI
DGAAVANCLI NVRGIEKVLL IKSSYKAREV MQSNNPPKNC REAFTAEGDQ VFNRRYYSSD
YLRPKYLSKD VEAEISLLEN EVASRKAQLA ASQQRLSSTE NEIKQNESHL HHHRQHQKEL
QIKIRRTAAE IADLENVDEI QYMDIRVLED VAEENKKKME TVKQEMQEES RKMEELNEIL
RAAEKRFEEI KEKMSQVEDI TNPIKDELDK ADSEVENRRR RLQYYEDKKK EHLTCIKKHK
ELLAAKEKEL EEKTAQARQI YSERIEVSRT VKSLDAEMNR LRERIKTEKS HRGNTEEIIQ
RFLDAKERYE DANSKVNNLK KFIRVLEEIM TQRFNIYRRF LRLLSLRCKL YFDHLLRIRG
CSGRILFDHK NETLLITVQP GEEDRPAPSN VRSLSGGERS FSTVCFILSL WSITESPFRC
LDEFDVYMDM LNRRIAMDMI LKVADSQCYR QFILLTPQSM SFLPVSSRIR ILRMQDPERG
QRTLTFRNRN EEEEDD
//
