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Database: UniProt
Entry: E1BXV5_CHICK
LinkDB: E1BXV5_CHICK
Original site: E1BXV5_CHICK 
ID   E1BXV5_CHICK            Unreviewed;      1991 AA.
AC   E1BXV5;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 4.
DT   25-OCT-2017, entry version 57.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000038088, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000038088, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000038088,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000038088}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000038088};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000038088}.
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DR   EMBL; AADN04000278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGALT00000038879; ENSGALP00000038088; ENSGALG00000006072.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    132    154       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    230    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    384    412       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    713    731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    743    764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    776    793       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    846    869       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    889    907       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    919    944       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1204   1222       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1243   1262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1274   1295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1315   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1439   1462       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1509   1532       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1552   1570       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1582   1601       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1637   1665       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1737   1760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      138    418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      474    662       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      713    948       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      958   1198       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1202   1470       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1517   1770       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      420    447       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1991 AA;  226601 MW;  B1E8DB24C4B2BC5A CRC64;
     MADFLLPGTN NFRKFTPESL AAIEKRIAAK KDHQKSTLDQ KPEEKPRPQL DLKAFQKLPA
     LYGNPPPELI GEPLEDLDPY YKDRKIFIVL NKQKTIFRFT ATRALWILSP FHPIRRTSGY
     VTVSYLMPYS LPSLPCLTLF TWFIICTIIT NCVFMAQNES SRSSSPSWNR YVEFTFTGIY
     TFESLIKILA RGFCLNEFTF LRDPWNWLDF SVIIMACQRQ SAVQKIKLKI GYIGNHLIIV
     GALIQSVKKL ANVMILTVFC LSVFALIGLQ LFKGNLRYKC VKKNHTDSTI RDFLRNKTWE
     SSATLADYAE HFAIKPGTSD VLLCGPGAGT CPPEHTCKQI GPNPDYGFTS FDTFGWAFLS
     LFRLMTQDYW ERLYQQTLRA SGKVYILFFM LVIFLGSFYL VNLILAVVTM AYEDQNKATI
     AETEAKERKF REAMELLQKE QESLTAKGID ILSISSFEGS PLSAKEIKER SNRKKRNKSL
     GIEECEEEQF PKSQLTDSQR KLSLLGLLYG PNANQVKRRL SHGSVFNFQI PAFEVDSKAD
     SADEEAHSTG ENKIQGRSMS VPQVGRRSSM PSQKSHGSHP ATPSCMQSSK WANTDDCNGM
     ISVMGGGHGK VHGLEDTAPS EGVMLPPVME DLGKSDLVRK NAILMEYFNE TFQRQRAASA
     VSIITSVLEE LEESQQKCPR FLKDFAFKYL IWNCCPLWLR IKKKVAAFIK DPFIDLTITL
     CIVMNTLFMA LEHNNMTENF KLMLKVGNLI FTGIFTAEMV LKIIALDPYY YFQQPWNIFD
     SIIVTLSLIE LSLPRQRGKK ERRKGGTLSV LRSFRLLRVF KLAKSWPTLN TLIKIIGNSL
     GALSNLTLVL AIIVFIFAIV GVQLFGGSYR TYGDKIKKNG EIRWHMMDFF HSFLVIFRIL
     CGEWIETMWD CMVVAEKPLC LLVFLLVMVI GNLVVLNLFI ALLLNSFSTD CLQTAEDDRE
     MNNLRIAFAR IHKGLRFVKS VMWDTCCGKL KHLKKAHRKK NKLTAQNPLG LGKERKNCKD
     NYNIEWAEKN GEICSGLDDF ITNPNVFVCV PIAEEENTSE GFEDEDKLST FSDTEYSKQE
     ENHLRQRGER GKTSGSWSKV SGLSSEEFSV LYLGKDRKVE SSPPEHKEFD SVSSSEGSTV
     DLTNPEDLLR QIPEFAEDKK TPEKCFSEGC VRYFHCCKGR AVNFGGKTWW NLRKTCYQIV
     EHSWFESFIV FMILLSSGVL AFEDIHINER RTIKAILSFL DRLFTFVFFL EMILKWVAYG
     FNKYFTNAWC WLDFLIVGVS LINILGSSLD GVKSLRTLRA LRPLRALSRF EGMRVVVNAL
     VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFGKCVNLT EENSELDSSI NDIADCKAWN
     HTGKIFWVNV KVNFDNVGSG YLALLQVATF KGWMEIMYAA VDSREKDEQP KMEYNLFMYL
     YFVNFIIFGS FFTLNLFVGV IIDNFNQQKK KINIFMTEEQ KKYYNAMKRL GSKKPQKPIP
     RPLNRYQGFL FDIVTNQAFD ITIMILICLN MVTMMVETYE QSDMKTNVLN KINILFVTIF
     STECVLKLVA LRQYYFSNAW NIFDIVVVIM SIVALLLSGI GKAFEHFLPP TLFRVIRLAR
     IGRILRLIRA AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IYAIFGMANF AYVKMEDGID
     DMFNFQTFAN SMLCLFEITT SAGWDGLLSP ILNTGPPYCD PNITGSIGEC GKPAIGIVYF
     VSYIIISFLI VVNMYIAVIL ENFNAATEES TEPLGEDDFD IFYEIWEKFD PEATQFITFS
     ALSDFADALA EPLRVPKPNK IELIAMDLPM VSGDRIHCLD ILFAFTKRVL GDSGEMDVLK
     VQMEDKFMAV NPSKKSYEPI STTLRHRQEE VSATVIQRAY RSHLLQRSIK HASYLYHHRT
     YSGDTLGDAA PEREGLIASM MGENYGRNLD ESQTSSSASL PPSYDSVTRA SSGNLIVENE
     FTGDQKSLDI K
//
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