ID E1CFF2_ORFV Unreviewed; 183 AA.
AC E1CFF2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Virus interferon resistance {ECO:0000313|EMBL:BAJ12034.1};
GN Name=VIR {ECO:0000313|EMBL:BAJ12034.1};
OS Orf virus (ORFV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Parapoxvirus.
OX NCBI_TaxID=10258 {ECO:0000313|EMBL:BAJ12034.1};
OH NCBI_TaxID=9925; Capra hircus (Goat).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1] {ECO:0000313|EMBL:BAJ12034.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HIS {ECO:0000313|EMBL:BAJ12034.1};
RX PubMed=20124763; DOI=10.1292/jvms.09-0467;
RA Inoshima Y., Ito M., Ishiguro N.;
RT "Spatial and temporal genetic homogeneity of orf viruses infecting Japanese
RT serows (Capricornis crispus).";
RL J. Vet. Med. Sci. 72:701-707(2010).
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DR EMBL; AB522798; BAJ12034.1; -; Genomic_DNA.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0039580; P:suppression by virus of host PKR signaling; IEA:UniProtKB-KW.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0039548; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity; IEA:UniProtKB-KW.
DR GO; GO:0039557; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity; IEA:UniProtKB-KW.
DR CDD; cd19875; DSRM_EIF2AK2-like; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR009179; E3L.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF02295; z-alpha; 1.
DR PIRSF; PIRSF004008; VAC_E3L; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00550; Zalpha; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50139; Z_BINDING; 1.
PE 4: Predicted;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Inhibition of host IRF3 by virus {ECO:0000256|ARBA:ARBA00022931};
KW Inhibition of host IRF7 by virus {ECO:0000256|ARBA:ARBA00022811};
KW Inhibition of host PKR by virus {ECO:0000256|ARBA:ARBA00023041};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023041};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 1..63
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 109..177
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
SQ SEQUENCE 183 AA; 19901 MW; 74C0BDE5DFE99D08 CRC64;
MACECASLIL ELLRKSDDKL PAKQIAKELG ISKHEANRQL YRLLDSDEVC CEDGNPPRWF
VECAPSAPTE EDENSDTEPM ETEAGCDTLF GGDIDIMTQS AVIRLKSLNP VSAVNEFCMM
THRPLEFSET RAGGEDHCPR FTCTITISGK VVAAADGASK KLARHTACSS ALTILINNCG
ISF
//
