ID E1CJL7_ANGJA Unreviewed; 150 AA.
AC E1CJL7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Relaxin-3 {ECO:0000256|ARBA:ARBA00040355};
GN Name=RLN3b {ECO:0000313|EMBL:BAJ22075.1};
OS Anguilla japonica (Japanese eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7937 {ECO:0000313|EMBL:BAJ22075.1};
RN [1] {ECO:0000313|EMBL:BAJ22075.1}
RP NUCLEOTIDE SEQUENCE.
RA Hu G., Kusakabe M., Takei Y.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAJ22075.1}
RP NUCLEOTIDE SEQUENCE.
RA Hu G.-B., Kusakabe M., Takei Y.;
RT "Localization of diversified relaxin gene transcripts in the brain of
RT eels.";
RL Gen. Comp. Endocrinol. 172:430-439(2011).
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; AB576117; BAJ22075.1; -; Genomic_DNA.
DR AlphaFoldDB; E1CJL7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR20968; ILGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20968:SF0; RELAXIN-3; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..150
FT /note="Relaxin-3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003144918"
FT DOMAIN 26..150
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 49..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 150 AA; 16013 MW; 9C456ACD5ED385C8 CRC64;
MWKAVVLAVS VLAAGTCAKE APEFGVKLCG REFIRAVIFT CGGSRWRRAA TSDDDASHNP
FSALHDETTG MSPNSVPGHP GPQLQHAAAP DWPREGEEAL SFGRAGRSAT LEDVLEALRS
TGRRERDVVV GLSNACCKWG CSKNEISSLC
//
