ID E1EWN8_GIAIA Unreviewed; 874 AA.
AC E1EWN8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Neurogenic locus notch-like protein {ECO:0000313|EMBL:EFO65328.1};
GN ORFNames=GLP15_3264 {ECO:0000313|EMBL:EFO65328.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO65328.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO65328.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO65328.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO65328.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACVC01000033; EFO65328.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EWN8; -.
DR STRING; 658858.E1EWN8; -.
DR EnsemblProtists; EFO65328; EFO65328; GLP15_3264.
DR VEuPathDB; GiardiaDB:GLP15_3264; -.
DR OMA; GGPISAC; -.
DR OrthoDB; 2877476at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07974; EGF_2; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01248; EGF_LAM_1; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..874
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003144770"
FT TRANSMEM 819..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..99
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..186
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 234..270
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 376..412
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 630..666
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 89..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 176..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 260..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 402..411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 656..665
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 874 AA; 92796 MW; 9F6D0617A38D0B29 CRC64;
MITLMISLFV AASLSCLTDY DCGYVGQCDW FGCKCPEGVS GISCEVNPCG IHRDPREQQP
IFHEGPYKTV ACSLAGTCVE DNGTYKCVCE EGFSGDTCEM KMCTSPADCN GQQCDSETGV
CVCEPGFNKG DCSIPTCNPI YDIVAKEYQY CGGSGTCTKA PELSGKLPPV RYYCDCNAGF
YGHSCENYDC TNGLFVCTND KHTCDRQTKQ CKCKPHHYGP DCGKNPCGII YHSIGDSIVK
QCNDRGTCRD DGPDNATCDC NEGWVGSDCS LEDCVINPSV CIAPLVCDHT LHICVCSNNL
IGQNCDSCRI GEYFAEAVSS CTPYSCISDV SAGVVCSDHG SCNTDTKSCD CSPDTVLIGT
QHCIPTNCLT QLSDGQKDYS VKNICSGRGT CKLVNGSYAC KCLTNYTGNL CQENPCQIVS
FTSIGAPVQT VYIECNGGGS CNDLTCRCRP GYSGSACELF SCNGIDSLCN GGTCVQDSFG
SWMCNCPVGS DLTDCSRKGC GSSTPQCSSN GACALKDFVS TTSAGVVVKR ISLHRCVCSL
HYKGLFCQRY DCEGDNANCN GGTCSENGEC TGCLEHFYGH DCRTNPCEID PLQGTECSAN
GVCQTVADPE TGEPTSVCKC KQGWFGTTCD KQSCPTVPCK HGGECIVSPD GNYCNCNEGF
SGVWCQDCVL PFKIVFVNGV AQCVPGSCVG EEGYCSGHGS CSSEQTCSCD YGYTTLGTDR
CVPDACIYKR DGIMNICGLQ GSCVVTESGA GCICSGDSSR RDDHSGFCMP LGCFSSSASK
TVCNGHGSCN IFFDSGEGIC ICNSGFTNDS GTCTLNAKIS AGIGVGVAML VAVIVFIILW
FTVIKKKLEE RKRRRFDGDS VRLLTNDTGD VSQL
//
