ID E1EZW8_GIAIA Unreviewed; 1231 AA.
AC E1EZW8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=GLP15_2722 {ECO:0000313|EMBL:EFO64251.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64251.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO64251.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO64251.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO64251.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACVC01000100; EFO64251.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EZW8; -.
DR STRING; 658858.E1EZW8; -.
DR EnsemblProtists; EFO64251; EFO64251; GLP15_2722.
DR VEuPathDB; GiardiaDB:GLP15_2722; -.
DR OMA; DEQERSW; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719}.
FT DOMAIN 504..621
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 171..205
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 231..272
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 333..478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1015..1042
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1231 AA; 136579 MW; 0444B4DFBC981EC7 CRC64;
MYLSEVEIRN FRSIVHTSVT GLHPGINVFI GINGAGKSNF YSAILFALMD PLYDLKTINR
AQILSNDAKT KSGYVKLIID LEGAAVGDFQ GKVSISRHFT ITTDSFYLND VLVTSDKVAN
FLSIMGFNPS SQGYTFAVQQ SKVTSLAMSA PKALLDAFNS STGTWEYDTR KQDALEKLRA
AREEREEAQK IYVQLKGRCS RLTERMNKNK EYLKLMAERR TAEHALATLT YDTLKEQHTR
LTTQKEALVE DCKAKRAQID AIRAEINVLT NELIPLQLQE NNVLAAERTV NDHIYYLIDS
CQYLSSFCTA KSQRSQEQED STTVRRRSAQ HALEEATLRE RSLLDELAKL KNTQYSLSSS
IRKQRIMLES QETDKRESLI KELDDISRNL INAEAEHAAI KSLQEEVKQE LECISKKLDV
YKTRETEINA SELLQNHTEL SEKKQRLNMD LSMKVKNLNE AENKVVHEEY QLSQLTREFL
DLAPANLAAG ANLCLSAIKE AKINGFRGFL AEHINAAVGS YPALESAIGS TGLYSLLVEK
RETATEIMRH IRQRLSSSPL SGKANFIVLD AVSPPCLQEI DSNCVPLASL ISTMDDTRPA
ILQALGTSYL TRSLEDAAKY SSEHNIDCYT VTGDVIQGSG VAIGGHRNFK RLKCGVALGL
SREALLGASL TKGQVSTEIE EIKQEVRKVT VEITKLEPLV SPLQEELSGI HAEILPLSGE
LTRLQNTEAK LHIDEQELCA RINTLSQIKQ SIEDSISSLT VSNKLSPAKV KLLRQELADN
ETNEKEIGKK IDTIQALVNK AAVDRMKTEA KMQNIDASGA QLELGMKERG DIDAQMMSLL
TGLEKANLEA LEFPLDRDGL APLLAGLKTL SEKLKSAISN KEELDAVAQL SAKFLSALTE
LSDNTKVAVA SCKEATSRHR QKIVSKEAEI EDLSRQLETI AMGFEALDLE NNDALQHYKK
AEIALREIPA PTADEMEVFQ REKAAAKISD EQERSWLVSY IAAKSQQMGE TPPISQRAID
QYDRAVREKD QLEKQLADVV EGEHAVEDLV MKLDVRRKAH FEEQFKLVDA RFSEIFHRIT
GGKGHLTLST HGDGEPDGIL VDATFANQAT KDVQMSGGQR TLTSLCFVLA TEQASNNSFL
LLDEPDACLD EAYRTVFANL LAERAAQGIQ VFVITFRTEI ITVANQCFAV SRVEDHTTIE
PVANAYALSV AADATTVGLL AEGRHSKLAD T
//
