ID   E1F2D6_GIAIA            Unreviewed;       734 AA.
AC   E1F2D6;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Dynamin {ECO:0000313|EMBL:EFO63396.1};
GN   ORFNames=GLP15_1865 {ECO:0000313|EMBL:EFO63396.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO63396.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO63396.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO63396.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO63396.1}.
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DR   EMBL; ACVC01000133; EFO63396.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1F2D6; -.
DR   STRING; 658858.E1F2D6; -.
DR   EnsemblProtists; EFO63396; EFO63396; GLP15_1865.
DR   VEuPathDB; GiardiaDB:GLP15_1865; -.
DR   OMA; IQRRKEC; -.
DR   OrthoDB; 1052588at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd08771; DLP_1; 1.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF21; DYNAMIN-1-LIKE PROTEIN; 1.
DR   Pfam; PF01031; Dynamin_M; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF02212; GED; 1.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 1.
DR   SMART; SM00302; GED; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
DR   PROSITE; PS51388; GED; 1.
PE   4: Predicted;
FT   DOMAIN          27..308
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          635..726
FT                   /note="GED"
FT                   /evidence="ECO:0000259|PROSITE:PS51388"
FT   REGION          526..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..564
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..586
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  79611 MW;  8CCF273A5E456233 CRC64;
     MSQIDKLIPI VNSLQDVFSA IGQDKTNIDL PQITVVGSQS AGKSSVLEAV CGRDVLPRSA
     GICTRRPLIL QLIPTKPGQF VKDEKGKTYE EWGEFLHTKD KKFVHYQEIC KEIVAETDRV
     TGGTLNVSPL PIRLKLFSPT VVPLTLVDLP GLVKNALPGQ PADIDVQIKK CVYEYIQKPN
     AVILAVSAAN ADLATSDALQ AAINCDPKGD RSVGVLTKID IVDKGTEATV VSILRNEVHY
     FKLGWIAVMN RSQKDIDAQK TIAKHLHDEE EFFRTHDYYK PLAAQSGAKY LARRLNQVLI
     NHIQIVLPDL KMKVHLQLDK YSRELASYGQ HLEGRAEMER ALLGLISSYE KEYKAILDGS
     SAGASKNELY GGARISYIFQ SVLPKMFDTI SIQEILNGED VRTLIRNSSG TRSSLFLSES
     AFELLVQKVV RRLEGPCKHC LQLVKAELIS IAKSIPTPEM KKYRRLCNEL VNTCIKLIND
     LTMPTGKFLQ DLIHSELCYI NTLHPDFVAS QEFKGHIDGQ RNMANLDVSN QGFGEGNFGG
     PGGPGMGGFP PGGPGAPGGP GGPGAPGGPG MNRGPGGPPG GPGGPGGPMN RGPGGPGGPG
     GPGGPGGPGP QQFNESVPEK IKAQGPLSEA EKLGVDLIPR LMSAYYRVIR KKIEDSVPKA
     CIAFLVKASM NQLQEVLVRN LYSGDKIEDL LCEDPSIKEK RVACRELVDV MQRASNILDK
     IGNIRNVEDL AKKD
//