ID   E1F2Q2_GIAIA            Unreviewed;       840 AA.
AC   E1F2Q2;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN   ORFNames=GLP15_878 {ECO:0000313|EMBL:EFO63273.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO63273.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO63273.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO63273.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO63273.1}.
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DR   EMBL; ACVC01000139; EFO63273.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1F2Q2; -.
DR   EnsemblProtists; EFO63273; EFO63273; GLP15_878.
DR   VEuPathDB; GiardiaDB:GLP15_878; -.
DR   OMA; IVMQTTI; -.
DR   OrthoDB; 5474929at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR22763:SF162; UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..840
FT                   /note="RING-type domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003145149"
FT   TRANSMEM        351..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        514..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        543..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          740..832
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   840 AA;  95609 MW;  9D993E66D102F405 CRC64;
     MLVSLISFGI LGTLAVRSAD PIQTELLVTS SLSKRHLNVV NQSRWTDSFR AIYSRIHSIV
     QRAPYFFNPS YCRLGSYDYY YSQEPFFISR PPALQEEGTV PSSPPDYIDV KLGPATTSYR
     GNWSIAQGNS GSLGLYTPSP ERAAGGMMLA SIFDLTWTTE YYTQTKDSGE LLTQPRNVSA
     AIYLMNGSYI NSDSHYFVGY GYYYPSQQKG LIKLIIPSLS KQPTLDLNIT EVDTYINGGA
     PWPSYVAGDD VLGDFKFNET CATSNVSDLE RPNTCDYYLF FSISNATRPI KGHIYPPDFA
     AQIRQEGRPL DGSTTEEIVP LVEYRLYSAK CCVDMQTRSL IYNSAQEMTQ AMIYGGVVSL
     FAILTAILSA HSLTKLVSPV RLAQLTMASI VMQTTIDALL AINGVNYAFE FQNSLGPLLL
     AAVAFFIICL IIDIQLLMLK QRQMMIDRNR GQNPQIGIKI YCIFYLVMLG SMIVSSYIPF
     KFLFYFFLLL SSYWVPQCYH MYRIRSPTMG YTYTYVIFTT ILRMIPIWYF YCYSKNFLGY
     ETVSFYQYLL FFWVFLQLTT MLVLMATHKS RYKAFIAKGS HSVYTYTDKL LSQHVLTDFD
     YVDYVSNQRK ETETPCEFLA RLESDAGQSF PFVMSYFQKP NSTIRAYSNH ATVTILPSSE
     ELQLESEFYQ HYCMNPLHKH SSLYSEDMTV AALSSCTAYL QSRLSYQQAL LHTDTKDPEG
     SLMNCFYMVK PKDVSDCVIC SICFDYITLT EKHINLFSES SKKAHELDSQ AVKDILEDIN
     TSGKLSGEEE PPQQKLSSDY DRDLWTTPCG HIFHAACLRR WMDETLQCPV DRAALPLPAY
//