ID E1F888_GIAIA Unreviewed; 759 AA.
AC E1F888;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EFO61332.1};
GN ORFNames=GLP15_1316 {ECO:0000313|EMBL:EFO61332.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO61332.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO61332.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO61332.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO61332.1}.
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DR EMBL; ACVC01000232; EFO61332.1; -; Genomic_DNA.
DR AlphaFoldDB; E1F888; -.
DR STRING; 658858.E1F888; -.
DR EnsemblProtists; EFO61332; EFO61332; GLP15_1316.
DR VEuPathDB; GiardiaDB:GLP15_1316; -.
DR OMA; HEQPERE; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF03028; Dynein_heavy; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 19..65
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 122..295
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 539..660
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT COILED 58..85
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 759 AA; 87247 MW; DDEB42D5EA8882BD CRC64;
MQENFDPLQL LTNDALIARW NNDKLPTDRV SLENASIFST AERWPLIIDP QLQGIAWIKA
REERRKEEER RFMELEAEYQ AKKATFEADR ERRMREAEEK GEKFVDDVVL ERPRPSDEKL
GRLQVVRFSQ NKWLDAIEKA VQDGDTVIIE NIHETIDAVL NPLLGRNIIK RGRSKFIKFG
DKEVEYDDNF RLYIQTKMPN PHYSPEIQAQ TTLINFTVTI DGLEDQLLAL VVSEERPDLE
ELKASLMRQQ NEFKITLQQL EEDLLKRLSS ATGDILGDTD LIENLEKTKA TSSEISEKVK
EAKVTEENIN KAREQYRPVA ARAAMLYFLL NSLNVIDHFY QFSLSAFITV FYRAIRLSQK
SEDVQERVNI LLDALTFDIY SYAARGLFER HKLIFISQLC FNVLRKDNNL PANEFNFLLR
GTASVSRENA LSEFIPTSSW NSVVGLAESI PDIFGKLPDD IEGSAKRWKE WIQHEQPERE
KLPQDWKNRT SLQRLCIIRA LRPDRLMTAM TDFVSESIGE KYVEALPFSF KNVYADSSKT
EPVFFILSPG VDPVKDVESL GKQLGFTADN GKFKAISLGQ GQEKFAEKAM EDMAQKGGWV
LLQNIHLMKI WQVKLEKMME QYCSETAHDN FRLFLSGEPD SDPAVASVLP GIVQMCIKVT
NEPPRGIKAN MNRAIGLFTP DTFEMCSKGN EFKSILFALI FFHAIVIERR KFGPIGYVRN
LCSCSMPLFY NVYVTMSVCQ YASTSNFPLL KYFITAPFC
//
