ID   E1IA04_9CHLR            Unreviewed;      1222 AA.
AC   E1IA04;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=OSCT_0155 {ECO:0000313|EMBL:EFO82006.1};
OS   Oscillochloris trichoides DG-6.
OC   Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Oscillochloridaceae; Oscillochloris.
OX   NCBI_TaxID=765420 {ECO:0000313|EMBL:EFO82006.1, ECO:0000313|Proteomes:UP000054010};
RN   [1] {ECO:0000313|EMBL:EFO82006.1, ECO:0000313|Proteomes:UP000054010}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG-6 {ECO:0000313|EMBL:EFO82006.1,
RC   ECO:0000313|Proteomes:UP000054010};
RX   PubMed=21037015; DOI=10.1128/JB.00931-10;
RA   Kuznetsov B.B., Ivanovsky R.N., Keppen O.I., Sukhacheva M.V.,
RA   Bumazhkin B.K., Patutina E.O., Beletsky A.V., Mardanov A.V., Baslerov R.V.,
RA   Panteleeva A.N., Kolganova T.V., Ravin N.V., Skryabin K.G.;
RT   "Draft genome sequence of the anoxygenic filamentous phototrophic bacterium
RT   Oscillochloris trichoides subsp. DG-6.";
RL   J. Bacteriol. 193:321-322(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO82006.1}.
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DR   EMBL; ADVR01000003; EFO82006.1; -; Genomic_DNA.
DR   RefSeq; WP_006560711.1; NZ_GL501401.1.
DR   AlphaFoldDB; E1IA04; -.
DR   STRING; 765420.OSCT_0155; -.
DR   REBASE; 29507; OtrDG6ORF155P.
DR   eggNOG; COG0827; Bacteria.
DR   eggNOG; COG1002; Bacteria.
DR   HOGENOM; CLU_002539_1_0_0; -.
DR   OrthoDB; 9815272at2; -.
DR   Proteomes; UP000054010; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR025931; TaqI_C.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF07669; Eco57I; 1.
DR   Pfam; PF12950; TaqI_C; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054010};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          769..865
FT                   /note="Type II methyltransferase M.TaqI-like"
FT                   /evidence="ECO:0000259|Pfam:PF07669"
FT   DOMAIN          996..1159
FT                   /note="TaqI-like C-terminal specificity"
FT                   /evidence="ECO:0000259|Pfam:PF12950"
SQ   SEQUENCE   1222 AA;  138596 MW;  31C9B6C000962E54 CRC64;
     MAPISLLASI KDSLTTLATA PLASAARDLL ATLGYQSQRW LEFEPTPAAF CALFDPDQRL
     NPAHARLSQW RSVAMLAQIT GEELAIHAQL HLNLGTPPNF NAQTYQSLLL FAVDLAPKPD
     DRPYTRGELA TITREINKLF LMPVSVVFRY AATLTLAIVT HRPNRHDANR DVLEKVSLIR
     DLDLCAPHRA HLEILADLSL PALLTRQTIS GFADLQRAWA RTLDSSELNR RFYREIANWY
     FWAVQVVEFP DDATPRPRRN ADRVIRLITR LIFIWFLREK GLVDPRLFRR TEVADLLVSL
     DDAASSYYLA ILQNLFFATL NQEMPKRAFR RPEQHYGITN LYRHAALFRD PQAALAIFAR
     IPFLNGGLFE CLDDPEQKPP LRIDGFSDRP DSQPSVPNAL FFTAQPLAVD LNSTYGTRGR
     RYEVRGLLEI LESYKFTVAE NTPIEEDVAL DPELLGQVFE NLLAAYNPET ETTARKETGS
     FYTPRHVVAY MVDESLLLYL KSQLPATADL DARLRELLAY NDLPPRFSPA EIAQLIRALD
     NLTMIDPACG SGAFPMGALQ KLVFLLNKLD PGNHAWKARQ IARAEEIEDT LAREAAIESI
     EEAFERNDLD YGRKLFLIEN VIYGVDIQPI AVQIAKLRCF ISLIVEQQVH DERDNRGIRP
     LPNLETKFVA ADALHSLTGQ GALRSDRVIA LEHQLKQVRS AYFSAKTPPT KRKYREQDRN
     LRQELQAQLE YEGMPKATAA ALAEWDPYAQ NRHAPFFDPE WMFGRDQGFA LVIANPPYVR
     QEQIKERKPA LQQRYATYTG TADLYVYFYE RGLQLLKPGG ILTFISSNKF FRAGYGQKLR
     NYLKQHTHIQ QIIDFGDAPV FTAIAYPSII IAQKHADAQP SSATPTEQRL LALNWNPASR
     LDEFPAIVAH ARAAAATPSG PLILQRSLSD DGWRLEGAAT QRLLEKLRRA GKPLGEYVGG
     RFYRGITTGL NEAFVIDRKT RDQLIAEDPS SAELIKPYIR GKDVKRWYVD FVDQYIIQIE
     SSENYKHSWS GTPYSEAEGI FAKTYPAIHT WLRNFHKDLT ERYDQGKYYW ELRACAYWND
     FKRTKIISTK ISRKPTFALD DSGYILGNTS YMISSVNNLY YPISLLNSTV SLFYAKQIFV
     GKQNGWYEVQ PPALEAFPIP PPEASNAIGG LVERILDLKA EASAADVGEL EREIDERVYA
     LYGLRPDEIR TIEEIVGGGE KA
//