ID E1IIC3_9CHLR Unreviewed; 626 AA.
AC E1IIC3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=OSCT_3074 {ECO:0000313|EMBL:EFO79073.1};
OS Oscillochloris trichoides DG-6.
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Oscillochloridaceae; Oscillochloris.
OX NCBI_TaxID=765420 {ECO:0000313|EMBL:EFO79073.1, ECO:0000313|Proteomes:UP000054010};
RN [1] {ECO:0000313|EMBL:EFO79073.1, ECO:0000313|Proteomes:UP000054010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG-6 {ECO:0000313|EMBL:EFO79073.1,
RC ECO:0000313|Proteomes:UP000054010};
RX PubMed=21037015; DOI=10.1128/JB.00931-10;
RA Kuznetsov B.B., Ivanovsky R.N., Keppen O.I., Sukhacheva M.V.,
RA Bumazhkin B.K., Patutina E.O., Beletsky A.V., Mardanov A.V., Baslerov R.V.,
RA Panteleeva A.N., Kolganova T.V., Ravin N.V., Skryabin K.G.;
RT "Draft genome sequence of the anoxygenic filamentous phototrophic bacterium
RT Oscillochloris trichoides subsp. DG-6.";
RL J. Bacteriol. 193:321-322(2011).
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO79073.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADVR01000131; EFO79073.1; -; Genomic_DNA.
DR RefSeq; WP_006563640.1; NZ_GL501404.1.
DR AlphaFoldDB; E1IIC3; -.
DR STRING; 765420.OSCT_3074; -.
DR eggNOG; COG1293; Bacteria.
DR HOGENOM; CLU_022481_2_1_0; -.
DR OrthoDB; 9766163at2; -.
DR Proteomes; UP000054010; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000054010};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 516..591
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT REGION 112..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 362..389
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
FT COMPBIAS 156..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 69599 MW; 3430A9399F25EFA6 CRC64;
MYFDALTMSA VADELRETIV GGRIQRVVLT GPLSIGLEIY QRGQRYHLLA SAHPQFARVH
LVQKRLSRGV EQATPLLLLM RKYLLGGRIV GIEQPHLERI LVLSIAKRAQ TRNQAEETEE
EAGLFPPPQP SPVGGGSLFP HLQPSGSLFP PPAGEDEGGG DDEPDEPWPD DAEQPALITC
DLIIEPMDRR SNIILVDDNN MVMESIKRVT PRMSQRVIMP RHVYELPPAQ AKRDPTRAMG
EGLAGLSAGL GGELEKALVT NYRGVSPQVA REVIFRSLGQ PKSAISADLP WYSLAARLRE
IFNPPWHPCL VRGPDGPLAY AAYHLNHLAN AQDGPSISAV LEEFYAAREE LTNHTQRRSA
LAQQLSAASE RLQHQCEQIR AELRKAGDLE VLRWEGEMIF AFLHALQPGQ TVLTVEGRKI
QLDPQRKPVE QAQERFKAYD KAKSALAGLP ELLNQVEMRI HGVEQLKALL LLSDDYDQIE
QIAIEAEEMG YLREHPDPIA KRRRHKSTKA RPLQVQSSDG FAIVIGRSAR QNEEVTFRIG
RPEDLWLHAR GIHGSHVIIR SAGREVPETT LLEAASLAAH FSQASHDASV EIDLCRRALV
RKVVGGPIGL VTYQAERTIR AVPRKP
//
