ID E1LBD8_9FIRM Unreviewed; 339 AA.
AC E1LBD8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Homocysteine S-methyltransferase {ECO:0000313|EMBL:EFL58144.1};
GN ORFNames=HMPREF9684_1409 {ECO:0000313|EMBL:EFL58144.1};
OS Veillonella atypica ACS-134-V-Col7a.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Veillonella.
OX NCBI_TaxID=866778 {ECO:0000313|EMBL:EFL58144.1, ECO:0000313|Proteomes:UP000005942};
RN [1] {ECO:0000313|EMBL:EFL58144.1, ECO:0000313|Proteomes:UP000005942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACS-134-V-Col7a {ECO:0000313|EMBL:EFL58144.1,
RC ECO:0000313|Proteomes:UP000005942};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFL58144.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEDS01000036; EFL58144.1; -; Genomic_DNA.
DR RefSeq; WP_005380266.1; NZ_AEDS01000036.1.
DR AlphaFoldDB; E1LBD8; -.
DR Proteomes; UP000005942; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR46015:SF1; ZGC:171603 PROTEIN; 1.
DR PANTHER; PTHR46015; ZGC:172121; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00333};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT DOMAIN 5..336
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 258
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 321
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 322
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 339 AA; 37112 MW; 56FB165468C4B00C CRC64;
MAKRKAFLKI VKENGPLVLD GAFGTELERH GCNIHDELWS SKMLIENPEI IKKVHISYLA
AGADIIESSG YQATVAGFKA HGYGTEEALD LVKLSVRLAV QARNEFLEAK ANDALTLRGI
TLGEQLPDGS VRYFSEGALP KPLVAASVGP YGAFLADGSE YRGDYGVQTE YLEVFHIPRI
ALFCEENPDV LACETVPCYD EAIAIARTLC DPLTTKGIPA WISFSCKDEH HISNGETIIK
CAEMIDKVRQ VTGIGINCTA PEYVESLIKD IRSVTNKPIA VYPNLGETYD GETKTWSGGQ
QSFIDYVDVW RKAGANIIGG CCRTNPDIIQ EVAKQIHVK
//
