ID   E1Q4E2_HELPP            Unreviewed;       275 AA.
AC   E1Q4E2;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:ADO07570.1};
DE            EC=1.3.1.12 {ECO:0000313|EMBL:ADO07570.1};
GN   OrderedLocusNames=HPPC_06810 {ECO:0000313|EMBL:ADO07570.1};
OS   Helicobacter pylori (strain PeCan4).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=765963 {ECO:0000313|EMBL:ADO07570.1, ECO:0000313|Proteomes:UP000006863};
RN   [1] {ECO:0000313|Proteomes:UP000006863}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PeCan4 {ECO:0000313|Proteomes:UP000006863};
RA   Kersulyte D., Vasquez J., Gilman R.H., Berg D.E.;
RT   "Complete genome sequence of Helicobacter pylori strain PeCan4.";
RL   Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002074; ADO07570.1; -; Genomic_DNA.
DR   RefSeq; WP_000643527.1; NC_014555.1.
DR   AlphaFoldDB; E1Q4E2; -.
DR   KEGG; hpc:HPPC_06810; -.
DR   HOGENOM; CLU_055968_2_0_7; -.
DR   Proteomes; UP000006863; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ADO07570.1}.
FT   DOMAIN          1..275
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   275 AA;  30429 MW;  0939B18429267A93 CRC64;
     MKAGIIGLGL MGGSLGLALQ EWGRFKSVTG YDHNALHAKL ALTLGLVDEC VEFEKILECD
     VIFLAIPVEG IIACLKKMTP IKKSATIIDL GGAKAQIIHN IPKSIRKNFI AAHPMCGTEF
     YGPKASVKGL YENALVILCD LEDSGTEQVE IAKEIFLGIK ARLIKMKSNE HDTHVAYISH
     LPHVLSYALA NSVLKQNDPE MILSLAGGGF RDMSRLSKSS PLMWKDIFKQ NRDNVLEAIK
     KCEKEIAQAK AWIENNDYES LAEWMAQANK LQEFM
//