ID E1QHI2_DESB2 Unreviewed; 741 AA.
AC E1QHI2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Metal dependent phosphohydrolase {ECO:0000313|EMBL:ADK85025.1};
GN OrderedLocusNames=Deba_1657 {ECO:0000313|EMBL:ADK85025.1};
OS Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / LMG 7858 / VKM B-1802
OS / 2st14).
OC Bacteria; Thermodesulfobacteriota; Desulfarculia; Desulfarculales;
OC Desulfarculaceae; Desulfarculus.
OX NCBI_TaxID=644282 {ECO:0000313|EMBL:ADK85025.1, ECO:0000313|Proteomes:UP000009047};
RN [1] {ECO:0000313|EMBL:ADK85025.1, ECO:0000313|Proteomes:UP000009047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33931 / DSM 2075 / LMG 7858 / VKM B-1802 / 2st14
RC {ECO:0000313|Proteomes:UP000009047};
RX PubMed=21304732; DOI=10.4056/sigs.1243258;
RA Sun H., Spring S., Lapidus A., Davenport K., Del Rio T.G., Tice H.,
RA Nolan M., Copeland A., Cheng J.F., Lucas S., Tapia R., Goodwin L.,
RA Pitluck S., Ivanova N., Pagani I., Mavromatis K., Ovchinnikova G., Pati A.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Han C., Rohde M., Brambilla E., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Land M.;
RT "Complete genome sequence of Desulfarculus baarsii type strain (2st14).";
RL Stand. Genomic Sci. 3:276-284(2010).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP002085; ADK85025.1; -; Genomic_DNA.
DR RefSeq; WP_013258478.1; NC_014365.1.
DR AlphaFoldDB; E1QHI2; -.
DR STRING; 644282.Deba_1657; -.
DR KEGG; dbr:Deba_1657; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_010123_0_0_7; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000009047; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009047}.
FT DOMAIN 14..177
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 233..419
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 741 AA; 81593 MW; 516BDC5D166C5D85 CRC64;
MAGEFYARPK DGAPEDQWQT IEEHLTNVAE EAGRMALAFG AGPWGRAAGL LHDLGKYSEA
FQRRLRGGPK VDHSTAGARR ARALFGPGWG KLLAYAIAGH HAGLANGNDG SPSDLVSRLG
ESRRKRQIEP YERFDPRLLA DLSLVAPPLK RDDERSGFQA AFFARMIFSC LVDADRLDSE
RFTSPDKAAW RDGWPDVDQL WTRLEAFLAG LRAKAAASPL NKRRNEILDA CLAAADQPPG
LFSLTVPTGG GKTYSSLAFA LRHAHGHGLR RVIYVIPYTS IIDQNASVMR DALGDDAVLE
HHSSLPVNDD QKDDGAAFRR GDLAAENWDA PLVITTNVQF FESLFANKPG KCRKLHNIAG
SVIILDEAQM LPRDQLRPCL AALRELTLNY GCSVVLCTAT QPAFGDAETF DSLAMRPREL
APDPERLYDE FRRVRVVLEG MLSADELAGR LAAHDQVLCV VNTRRHARDV FRRLAAGRPT
GQVYHLSTLM HATHRRAKLE AIRADLAAGR PCLAVSTQLV EAGVDVDFPH VYRAMAGLDS
LAQAAGRCNR EGRLAELGLL HVFDCDKQEY KPPHSLIAPM EEGRGVLRRC AAGDDLLSLA
NIGDYFAGLY HRHKDRLDVG DILAELAPGA KNADFPFATV ADLFKYFDSP GQPLLVCDEN
LRRRIVDGLR HAPNPGLFLR RAQPWLVQIY DHEIGQLERK GAVSRVVEGG LAVLEEPALY
RDDVGLDIDL DAPGDPNKTY Y
//
