ID E1QHV9_DESB2 Unreviewed; 378 AA.
AC E1QHV9;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ADK85152.1};
GN OrderedLocusNames=Deba_1785 {ECO:0000313|EMBL:ADK85152.1};
OS Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / LMG 7858 / VKM B-1802
OS / 2st14).
OC Bacteria; Thermodesulfobacteriota; Desulfarculia; Desulfarculales;
OC Desulfarculaceae; Desulfarculus.
OX NCBI_TaxID=644282 {ECO:0000313|EMBL:ADK85152.1, ECO:0000313|Proteomes:UP000009047};
RN [1] {ECO:0000313|EMBL:ADK85152.1, ECO:0000313|Proteomes:UP000009047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33931 / DSM 2075 / LMG 7858 / VKM B-1802 / 2st14
RC {ECO:0000313|Proteomes:UP000009047};
RX PubMed=21304732; DOI=10.4056/sigs.1243258;
RA Sun H., Spring S., Lapidus A., Davenport K., Del Rio T.G., Tice H.,
RA Nolan M., Copeland A., Cheng J.F., Lucas S., Tapia R., Goodwin L.,
RA Pitluck S., Ivanova N., Pagani I., Mavromatis K., Ovchinnikova G., Pati A.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C.,
RA Han C., Rohde M., Brambilla E., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Land M.;
RT "Complete genome sequence of Desulfarculus baarsii type strain (2st14).";
RL Stand. Genomic Sci. 3:276-284(2010).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP002085; ADK85152.1; -; Genomic_DNA.
DR AlphaFoldDB; E1QHV9; -.
DR STRING; 644282.Deba_1785; -.
DR KEGG; dbr:Deba_1785; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_7; -.
DR OrthoDB; 9772050at2; -.
DR Proteomes; UP000009047; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000009047};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 53..282
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 283..350
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT COILED 93..158
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 378 AA; 40705 MW; 33E398BD49449826 CRC64;
MLYLYTLFFL QGQPQAESAP PPAADPEVSV ITLSHQQVAL DSELTGRTTP FLIAEVRPQV
GGIINKRLFE EGSDVKAGQA LYQIDPATYK ATMDSARAAL AKAEANLFAA QLKSQRYKDL
VAIKAVSQQN YDDAYADLKQ AEADVAACKA ALETARINLE YTKVTSPISG RIGRSSVTAG
ALVTASQQAS LATVQQLDPI YVDVTQSSSE MLRLKRQLAS GQLKRDEHNK AKVRLILEDG
VTYPLEGELQ FSDVTVDQTT GAVTLRAVFP NPEQELLPGM YVRAILETGV NDRAILVPQR
AVARNNKGEA TVLVLDEQNR VQTRTLGLGR AVGADWLVNS GLRAGERVIM EGSQKVAPGA
IAKAVAFQPA ASAADDKR
//
