ID E1QWN1_OLSUV Unreviewed; 348 AA.
AC E1QWN1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:ADK68534.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:ADK68534.1};
GN OrderedLocusNames=Olsu_1431 {ECO:0000313|EMBL:ADK68534.1};
OS Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 /
OS NCIMB 702895 / VPI D76D-27C) (Lactobacillus uli).
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=633147 {ECO:0000313|EMBL:ADK68534.1, ECO:0000313|Proteomes:UP000000333};
RN [1] {ECO:0000313|EMBL:ADK68534.1, ECO:0000313|Proteomes:UP000000333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / NCIMB 702895 /
RC VPI D76D-27C {ECO:0000313|Proteomes:UP000000333};
RX PubMed=21304694; DOI=10.4056/sigs.1082860;
RA Goker M., Held B., Lucas S., Nolan M., Yasawong M., Glavina Del Rio T.,
RA Tice H., Cheng J.F., Bruce D., Detter J.C., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Rohde M., Sikorski J., Pukall R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Olsenella uli type strain (VPI D76D-27C).";
RL Stand. Genomic Sci. 3:76-84(2010).
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DR EMBL; CP002106; ADK68534.1; -; Genomic_DNA.
DR RefSeq; WP_013252286.1; NZ_JQCO01000001.1.
DR AlphaFoldDB; E1QWN1; -.
DR STRING; 633147.Olsu_1431; -.
DR GeneID; 78512828; -.
DR KEGG; ols:Olsu_1431; -.
DR PATRIC; fig|633147.7.peg.90; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_11; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000000333; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ADK68534.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000333}.
FT DOMAIN 8..167
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 170..286
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 348 AA; 36354 MW; A22F35DDD2BE66A2 CRC64;
MAVQKIRRVA FVGTGIMGAP IAGHVLDAGF GLTVHNRSRE KADGLVARGA TWADSPAAAA
AEADVVFTMV GYPDDVEDVY LGAGGILEAA KKGAWLVDLT TSSPTLAREL HDAAEVVGKH
AFDCPVTGGQ SGAEAGTLTL MVGAGEDDAR ILLPVLESFS SKVYYFGAAG RGQAAKLCNQ
VSLASCMMGY ADALALAEQS GLDLDQVVDM MCDGMGGSAA MERLAPKSVA GDFRPGFLAE
HLRKDLGLAL MRADDLDLTL PGAETAFNLY DTLCTVGGSR LGTQAISLLY ADEQTGFAAG
LDWSRLDASE WEDEPGCAHD HCDHDHRGDG HGHCEHDHCG CGHHHGEA
//
