ID E1RH80_METP4 Unreviewed; 688 AA.
AC E1RH80;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Formate dehydrogenase, alpha subunit {ECO:0000313|EMBL:ADN36384.1};
GN OrderedLocusNames=Mpet_1628 {ECO:0000313|EMBL:ADN36384.1};
OS Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)
OS (Methanoplanus petrolearius).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanolacinia.
OX NCBI_TaxID=679926 {ECO:0000313|EMBL:ADN36384.1, ECO:0000313|Proteomes:UP000006565};
RN [1] {ECO:0000313|EMBL:ADN36384.1, ECO:0000313|Proteomes:UP000006565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11571 / OCM 486 / SEBR 4847
RC {ECO:0000313|Proteomes:UP000006565};
RX PubMed=21304750;
RA Brambilla E., Djao O.D., Daligault H., Lapidus A., Lucas S., Hammon N.,
RA Nolan M., Tice H., Cheng J.F., Han C., Tapia R., Goodwin L., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Rohde M.,
RA Spring S., Sikorski J., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Methanoplanus petrolearius type strain (SEBR
RT 4847).";
RL Stand. Genomic Sci. 3:203-211(2010).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002117; ADN36384.1; -; Genomic_DNA.
DR RefSeq; WP_013329561.1; NC_014507.1.
DR AlphaFoldDB; E1RH80; -.
DR STRING; 679926.Mpet_1628; -.
DR GeneID; 9744100; -.
DR KEGG; mpi:Mpet_1628; -.
DR eggNOG; arCOG01492; Archaea.
DR HOGENOM; CLU_000422_4_0_2; -.
DR OMA; NVGTDIP; -.
DR OrthoDB; 23466at2157; -.
DR Proteomes; UP000006565; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0015942; P:formate metabolic process; IEA:InterPro.
DR CDD; cd02790; MopB_CT_Formate-Dh_H; 1.
DR CDD; cd02753; MopB_Formate-Dh-H; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041925; CT_Formate-Dh_H.
DR InterPro; IPR041924; Formate_Dh-H_N.
DR InterPro; IPR006478; Formate_DH_asu.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR027467; MopterinOxRdtase_cofactor_BS.
DR NCBIfam; TIGR01591; Fdh-alpha; 1.
DR PANTHER; PTHR43105:SF13; NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS00551; MOLYBDOPTERIN_PROK_1; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000006565}.
FT DOMAIN 3..59
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
SQ SEQUENCE 688 AA; 76956 MW; 34F8365B146DAE1E CRC64;
MDFKYVQTTC PYCGTGCTFN LAVRDGKVTG TAPYYRSPIN EGKVCPKGTY AWQFINHKDR
LKKPLVRKDG KYVETTWDEA YSIIAENFKK YQPEECAVLS SARCSNEDNY ALMKFARGVL
KTRHIDHCAR LCHASTVVGL AASFGSGAMT NSIPDISESK CIFCLGSNTF EQHPLIGRQI
MKAKAAGAKF IYADPRFTPT ARQSDLYMQF YSGGDVAILN CMMGEIIRNG WEDKDFIEKR
TKDYEELKKI VLLERYTPEV VGELVGVPAE SLRTAAEWFG KAESATVLYS MGLTQHTVGV
DNVKSTANLL MLTGNIGIPG GGVNALRGQN NVQGSCDMGA LPNVFTGYQK VVDGPVRKKF
EDAWGFPDGI AEPKNGFEIT TMFNVLHDDP GRLKAMYLMG ENPLLSEPDL NHVEEAIQNL
DFLVVQDIFF TETCEYAHVV LPATCFAEKD GCQTNTERRV QRWRKAQEPP GEAKEDWRII
SELSAVMGYA DQFPYTSPED VFNEIAELTP SYHGMNYERI GTPEALHWPC PTVDHPGTPI
LHTEKFATPD GLGVFHAIEW KAPAEVPDEE YPYRFTTGRI IWHYHTGSMT RRSKALDDEV
KTGWVEINEE DAKELGVRNG EMVKVVSRRG EITVAAKVME DIKKGVMFMP FHFVECAANR
LTNNALDPLA KIPEFKACAV KIETIEEA
//