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Database: UniProt
Entry: E1RJD5_METP4
LinkDB: E1RJD5_METP4
Original site: E1RJD5_METP4 
ID   E1RJD5_METP4            Unreviewed;       568 AA.
AC   E1RJD5;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Mpet_1991 {ECO:0000313|EMBL:ADN36741.1};
OS   Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)
OS   (Methanoplanus petrolearius).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanomicrobiales;
OC   Methanomicrobiaceae; Methanolacinia.
OX   NCBI_TaxID=679926 {ECO:0000313|EMBL:ADN36741.1, ECO:0000313|Proteomes:UP000006565};
RN   [1] {ECO:0000313|EMBL:ADN36741.1, ECO:0000313|Proteomes:UP000006565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11571 / OCM 486 / SEBR 4847
RC   {ECO:0000313|Proteomes:UP000006565};
RX   PubMed=21304750;
RA   Brambilla E., Djao O.D., Daligault H., Lapidus A., Lucas S.,
RA   Hammon N., Nolan M., Tice H., Cheng J.F., Han C., Tapia R.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Chang Y.J., Jeffries C.D., Rohde M., Spring S., Sikorski J., Goker M.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Methanoplanus petrolearius type strain
RT   (SEBR 4847).";
RL   Stand. Genomic Sci. 3:203-211(2010).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP002117; ADN36741.1; -; Genomic_DNA.
DR   RefSeq; WP_013329918.1; NC_014507.1.
DR   STRING; 679926.Mpet_1991; -.
DR   EnsemblBacteria; ADN36741; ADN36741; Mpet_1991.
DR   GeneID; 9744470; -.
DR   KEGG; mpi:Mpet_1991; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   HOGENOM; HOG000225809; -.
DR   KO; K00399; -.
DR   OMA; QVWLGSY; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000006565; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006565};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000006565};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:ADN36741.1}.
FT   DOMAIN        8    278       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      326    459       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       157    157       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     267    267       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     281    281       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   568 AA;  63031 MW;  FE438A24D9CC4083 CRC64;
     MGKIERSQKL FLNALKEKFQ GQDIESERTT FYNFDGVRQS PRKREFMAET VEIEKKRGIS
     MYDPERCHLG GIPMGQRQLM TYEVSGTNTF VEGDDLHFVN NAAMQQMWDE IRRTVIVGMD
     MAHATLQKRL GKEVTPETIN EYLHILNHAM PGGAVVQEHM VETHPALTDD CFVKVFTGDD
     ELADDIDPQY LINIDKLFPE NQAAELKEEV GKSIFQAIHI PTIVSRTCDG GTTSRWSAMQ
     IGMSFIAAYR MCAGEAAVAD LSFAAKHAGV IQMGTILPAR RARGPNEPGG IKFGFFGDMI
     QANRKYPNDP AKAALEVVGG GCMLFDQIWL GSYMSGGVGF TQYATAAYTD NILDEFTYYG
     MDYIGDKYNV DWKNPSPSDK IKPTQDIVND IATEVCLNAM EQYEQFPTMM EDHFGGSQRA
     GVMAAACGLS TSIATGNSNA GLNAWYLCML MHKDGWSRLG FFGYDLQDQC GSANSLSMEP
     DRGLVGEFRG PNYPNYAMNV GHQGEYAAIV SSAHYGRGDG YCLQPLIKIT FADPSLTFDF
     AEPRREFARG AIREFSPAGE RSLIIPAR
//
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