ID E1U3T9_9CYAN Unreviewed; 758 AA.
AC E1U3T9;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=(P)ppGpp synthetase I {ECO:0000313|EMBL:ACN96096.1};
OS Fischerella sp. MV11.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Hapalosiphonaceae;
OC Fischerella.
OX NCBI_TaxID=397321 {ECO:0000313|EMBL:ACN96096.1};
RN [1] {ECO:0000313|EMBL:ACN96096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MV11 {ECO:0000313|EMBL:ACN96096.1};
RA Hess W.R., Scholz I.D.;
RT "High diversity of cyanobacterial nonribosomal peptide synthetase genes in
RT isolates from geothermal sites and hot springs of Costa Rica.";
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; FJ211389; ACN96096.1; -; Genomic_DNA.
DR AlphaFoldDB; E1U3T9; -.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
FT DOMAIN 66..165
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 408..471
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 681..755
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 758 AA; 86478 MW; E4825C871CED8365 CRC64;
MSSTIVNHPI DITLPEWLES CLHTPPVDGA ATEEDRKYYD TSLICRAFEF AYQLHQGQYR
KSGEPYICHP IAVAGMLRDL GGSAAMIAAG FLHDVVEDTD VTIEEIEQRF GSEVRCLVEG
VTKLSKINFK SKTESQAENF RRMFLAMAQD IRVIVVKLAD RLHNMRTLEY MPDEKRRRTA
TETREIFAPL ANRLGIWRFK WELEDLAFKY LEPEAFRQIQ QLVSEKRTDR EERLKKISET
LRTRLAEAGI RCLDISGRPK HLYSIYQKMQ RQNKEFHEIY DLAALRIIVQ TNEECYRALA
VVHDVFRPIP GRFKDYIGLP KPNRYQSLHT GVIGPWGRPL EVQIRTMEMH HVAEYGIAAH
WKYKETGGSH TGLTASDEKF TWLRQLLEWQ SDLKDAQEYL ESIKDNLFEE DIYVFTPKGD
LVALKPGSTT VDFAYRIHTE VGNRCTGVRV NGRMVPLSTR LQNGDIVEII TQKNGHPSLD
WLNFVRTSAA KNRIKQWYKR SRREENIARG RELLEKELGK TGFDNVLKSE AMQAVAERCN
YHSTEDLLAG LGYGEVTLNL VLNRWREIVK AQQPATNEPD ITTHLPTTAK AAAFLREATP
ITSRTSDSPI VGVEGLLYHL AGCCTPIPGE AIIGVVTRGK GISIHRQGCH NLEKVECDRL
VPVSWNQAVE HSGRPVTYAV NLQIEALDRV GVLKDILSRL SDQGINVRHA NVKTSFGQPA
LIDLGIEIRD RPQLEQLFTQ IKKMSDILNI RRIGQIDE
//
