ID E1U5N7_ADE06 Unreviewed; 369 AA.
AC E1U5N7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Core-capsid bridging protein {ECO:0000256|HAMAP-Rule:MF_04053};
DE AltName: Full=Core protein V {ECO:0000256|HAMAP-Rule:MF_04053};
GN Name=L2 {ECO:0000256|HAMAP-Rule:MF_04053,
GN ECO:0000313|EMBL:ACN88108.1};
GN Synonyms=pV {ECO:0000313|EMBL:ADV03660.1};
OS Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus C.
OX NCBI_TaxID=10534 {ECO:0000313|EMBL:ACN88108.1, ECO:0000313|Proteomes:UP000142020};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACN88108.1, ECO:0000313|Proteomes:UP000142020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tonsil 99 prototype {ECO:0000313|EMBL:ACN88108.1};
RX PubMed=21849694; DOI=10.1128/JCM.00156-11;
RA Walsh M.P., Seto J., Liu E.B., Dehghan S., Hudson N.R., Lukashev A.N.,
RA Ivanova O., Chodosh J., Dyer D.W., Jones M.S., Seto D.;
RT "Computational analysis of two species C human adenoviruses provides
RT evidence of a novel virus.";
RL J. Clin. Microbiol. 49:3482-3490(2011).
RN [2] {ECO:0000313|EMBL:ADV03660.1, ECO:0000313|Proteomes:UP000155350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-6 {ECO:0000313|EMBL:ADV03660.1};
RX PubMed=21251688; DOI=10.1016/j.virol.2010.10.041;
RA Weaver E.A., Hillestad M.L., Khare R., Palmer D., Ng P., Barry M.A.;
RT "Characterization of species C human adenovirus serotype 6 (Ad6).";
RL Virology 412:19-27(2011).
RN [3] {ECO:0000313|EMBL:BAU36429.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=870550 {ECO:0000313|EMBL:BAU36429.1}, 930113
RC {ECO:0000313|EMBL:BAU36516.1}, and 940162
RC {ECO:0000313|EMBL:BAU36560.1};
RA Iida M.;
RT "Draft genome of Human adenovirus isolates of Fukui 3.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Associates loosely with the viral DNA to form an outer shell
CC around the nucleoprotein-DNA complex and links it with the capsid by
CC binding the endosome lysis protein. Dissociates from the viral genome
CC during entry. Might be involved in nuclear capsid assembly of the viral
CC particles through its association with NPM1/nucleophosmin.
CC {ECO:0000256|HAMAP-Rule:MF_04053}.
CC -!- SUBUNIT: Monomer. Homodimer. Exists in equilibrium between monomers and
CC dimers in solution. Interacts with the histone-like nucleoprotein; this
CC interactions bridge the virus core to the capsid. Interacts with core
CC protein X; this interactions bridge the virus core to the capsid.
CC Interacts with the endosome lysis protein VI; this interactions bridge
CC the virus core to the capsid. Interacts with the peripentonal hexons.
CC Interacts with host NPM1; this interaction might play a role in virus
CC assembly. {ECO:0000256|HAMAP-Rule:MF_04053}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|HAMAP-Rule:MF_04053}. Host
CC nucleus, host nucleolus {ECO:0000256|HAMAP-Rule:MF_04053}. Note=Located
CC inside the capsid (core). Present in 157 copies per virion. Localizes
CC in the nucleoli during infection, then translocates from the nucleoli
CC to the nucleoplasm as the infection progresses and is finally
CC incorporated into the viral particles. {ECO:0000256|HAMAP-
CC Rule:MF_04053}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC {ECO:0000256|HAMAP-Rule:MF_04053}.
CC -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC are produced by alternative splicing and alternative polyadenylation of
CC the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC present in the N-terminus of all these mRNAs and is recognized by the
CC viral shutoff protein to provide expression although conventional
CC translation via ribosome scanning from the cap has been shut off in the
CC host cell. {ECO:0000256|HAMAP-Rule:MF_04053}.
CC -!- MISCELLANEOUS: This protein is only encoded by mastadenoviruses, and
CC may therefore play a role in mammals tropism. {ECO:0000256|HAMAP-
CC Rule:MF_04053}.
CC -!- SIMILARITY: Belongs to the adenoviridae core-capsid bridging protein
CC family. {ECO:0000256|ARBA:ARBA00008293, ECO:0000256|HAMAP-
CC Rule:MF_04053}.
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DR EMBL; FJ349096; ACN88108.1; -; Genomic_DNA.
DR EMBL; HQ413315; ADV03660.1; -; Genomic_DNA.
DR EMBL; LC068712; BAU36429.1; -; Genomic_DNA.
DR EMBL; LC068713; BAU36473.1; -; Genomic_DNA.
DR EMBL; LC068714; BAU36516.1; -; Genomic_DNA.
DR EMBL; LC068715; BAU36560.1; -; Genomic_DNA.
DR Proteomes; UP000142020; Genome.
DR Proteomes; UP000155350; Genome.
DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04053; ADV_CORE5; 1.
DR InterPro; IPR005608; Adeno_V.
DR Pfam; PF03910; Adeno_PV; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_04053};
KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04053};
KW Late protein {ECO:0000256|HAMAP-Rule:MF_04053};
KW Viral capsid assembly {ECO:0000256|HAMAP-Rule:MF_04053};
KW Viral release from host cell {ECO:0000256|HAMAP-Rule:MF_04053};
KW Virion {ECO:0000256|HAMAP-Rule:MF_04053}.
FT REGION 15..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..341
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 369 AA; 41661 MW; 7BA907798B250F61 CRC64;
MSKRKIKEEM LQVIAPEIYG PPKKEEQDYK PRKLKRVKKK KKDDDDDELD DEVELLHATA
PRRRVQWKGR RVRRVLRPGT TVVFTPGERS TRTYKRVYDE VYGDEDLLEQ ANERLGEFAY
GKRHKDMLAL PLDEGNPTPS LKPVTLQQVL PALAPSEEKR GLKRESGDLA PTVQLMVPKR
QRLEDVLEKM TVEPGLEPEV RVRPIKQVAP GLGVQTVDVQ IPTTSSTSIA TATEGMETQT
SPVASAVADA AVQAAAAAAS KTSTEVQTDP WMFRVSAPRR PRRSRKYGAA SALLPEYALH
PSIAPTPGYR GYTYRPRRRA TTRRRTTTGT RRRRRRRQPV LAPISVRRVA REGGRTLVLP
TARYHPSIV
//