ID E1VJV4_9GAMM Unreviewed; 4229 AA.
AC E1VJV4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Non-ribosomal peptide synthetase modules and related proteins {ECO:0000313|EMBL:CBL45096.1};
GN ORFNames=HDN1F_15130 {ECO:0000313|EMBL:CBL45096.1};
OS gamma proteobacterium HdN1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria.
OX NCBI_TaxID=83406 {ECO:0000313|EMBL:CBL45096.1, ECO:0000313|Proteomes:UP000002677};
RN [1] {ECO:0000313|EMBL:CBL45096.1, ECO:0000313|Proteomes:UP000002677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HdN1 {ECO:0000313|Proteomes:UP000002677};
RA Widdel F., Rabus R., Grundmann O., Werner I., Schreiber F., Ehrenreich P.,
RA Behrends A., Wilkes H., Kube M., Reinhardt R., Zedelius J.;
RT "Alkane degradation by a new type of denitrifying bacterium with possible
RT involvement of the electron acceptor in substrate activation.";
RL Environ. Microbiol. 0:0-0(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FP929140; CBL45096.1; -; Genomic_DNA.
DR STRING; 83406.HDN1F_15130; -.
DR KEGG; gpb:HDN1F_15130; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_223888_0_0_6; -.
DR Proteomes; UP000002677; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 3.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 2.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002677}.
FT DOMAIN 1031..1105
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2564..2638
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4133..4208
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 36..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4229 AA; 472807 MW; 51DB696429E5FBE5 CRC64;
MLSEQEKQAT RYMNDKQLLK RLASLSPEQR ETLLKQLQKK KAQAPQTRRE GVRAYPRGEH
PLPLSYAQQR LWFLDQFESG EGSTYNISAA LRLTGELDVE ALRMAFEEIV NRHEALRTTF
VADDGQGRQV IGALQRWELL TISLEPLSVA EQEEVIARRF RGDSQTAFDL INGPLLRTRL
IRLARDRHVL IVTMHHIVSD GWSMGVLIRE VATLYSAFRS DQTSPLAPLK IQYADYAQWQ
REWLAGERLD RQLSYWRTRL EGVPILELPT DFPRSPVLTH EGASVLFEID AVTTQAVLEL
SRKQGVTLFM ALLSAMQVLL YRYSGQNDIC VGTPIAGRTR PELEELIGCF VNTLAIRSDL
SEQPSFSSLL KQVQQNLTGA YDHQDIPFER LVDELGIPRE LSHTPLFQVM FVLQNATSTQ
ALNLPGLSME VLPEESYTAK FDITLAMREE GGKLKGSWEY RTTLFSESTI RRMQAHLVQV
LKQAAANPSI AVDEIELLSA IEQKQLLVDW NSTKRPYPRD ASLGKIFESV VDRFADRIAV
RESGFNLTYR ELDSRANAIA QELLLAGVKP GHRVGLCADR CAGLVAAVLG IIKVGASYVP
LDPAYPTDRL VYMLEDAAVN VLISHSHLRD RLPVENAQVI VLDSFCGSKT EESSVWGKRP
EVEVSATAPA YVMYTSGSTG KPKGIEVVHR NILRLALNTD FMQLDEHVVF LQYAPISFDA
ATLELWGPLL NGGSVAIAPP GQLDPEGLGA FMRDTGTNAA WLTAALFHFF VQFHLEELRT
LKQLLAGGDV LSPALVRKAL TGIPGLVLIN GYGPTENTTF TCCYPMRSIG DVRNTVPIGR
PIANTRVYVL DANRRPVPRG VPGELYTSGD GVANGYLNRD ELSREVFLPN PFDAGGDPVM
YKTGDLVRYY DDGNLEYLGR IDQLVKIRGF RIELGEIEQA IAAINTIEQV AVIAREDTPG
VKKLVAYVVP VRGQIPTSHE LRSELKQRLP EYMVPSAFVV LESLPVTANG KLDRRALPKP
AFEDAHAQKV GPRDEKERVL VEIWQQVLNL QDIGVHDNFF ELGGDSILSI QITSRAKVAG
LHITTKQVFE NQTIAELAVV ASDVEAPVLA EQGLVHGEVI LAPVQQWFFD HEFTQEQHWN
QSVLLDLKPE FAFTEAQIKK ALCAVVLQHD ALRLRFERSG HNVRQFHDEN PDGNAHFTLR
QIDLNVRENE RPDDAITREC NSLQASLDLQ GGPLLAAGLI CVPKAGRKLL LVIHHLVIDG
VSWRVLLDDF IRALQAVQKH DDVSLGLKTT SYKQWADALA EHVRSGEFDN ELEYWRNTLA
GAEVNLPIDF PEGSNNVVYQ QVTSARLAPE RTSHLLREVN RAYRTEINDL LLTALAKTLA
DWTGRTDILI DMEGHGREIF NDRVDLSRTV GWFTSIYPVR LAYDSALGLA SNLKANKQRL
HSMPNRGFGF GGLKSFSQSD ALRREFAARP KSEIVFNYLG QFDSLIENSP WFAVATASRG
DEHSLESELP HTLSINSHIV EGALQVDWIY SADRFSEGTI QALADAYIAN LQRLIEHCLS
PDTFGYTPSD FPLAGLDQLS IDRLFGHTAG IEAVYPLSPM QEGMLFHSMF EDGSTAYFEQ
LSVEVMGDAN RELLLEAWGQ VIRRHPIMRS AFHWQDMPRP LQVVHTNINV EMNTFDWRDT
DPSQVESKLS TWMTRDRQRG FEVERPGLTR MSWIDLPGRR ARMIWSFHHV VLDGWSLPLV
IGEVFMIYTA LAKGRAPQLP AAGRYEDFIG WLERSDKEGA LKFWKRYMEG FQAPTPLAGK
KPLANSDIKH DYADELIHYS SEFTGRLQQF ARENHVTLNT LIQGAWGILL SRYSGENDVV
FGTTVSGRPA ELAGVEHIVG LFINTLPLRL RLNSDTRVVP LLQAMQEEAM DIRRFESTPL
VDIHRTTEVP GDQSLFESIL VFENYPIGQA VHEADELLDV GNIATIEHTN YPLTLIVMPG
ASLEVRLSYD ATLFDRPAVQ RILDHLEVIL KSALAQPDVP VLRIPILRDD ERNNALHAWN
PADSAYPRNK CVDDVFEEVV LRAPHALAAV DGDYRYTYEE INARANRLAR YIIEQGVEDQ
DFVAIALERS VDMLVAMLAT LKAGCAYLPV DPFYPEERIN FMLADTRAPV VITRTEYRER
ILPAMQALEK PSREILLDTD SQRILEKSSS DLKLRHNSDP QRVAYAVYTS GSTGKPKGVV
CTHIAITRLV MGANYFQLAP HDRMAHLSNV SFDAATWEIW GAFLNGASLV VFQKEQLLTP
EAFAAEVDRT KVNCVFITTA LFNAFAIHQP QLFPNLKYLL FGGEACDPQQ VRKIARHYKP
EHFLHVYGPS ENTTYSTWYE IQDVADNALT VPIGRSISGS TAYILDKYLQ PVPVGVAGEI
YVGGDGLAVG YLNDPEKTAA AFVPNPLVAG GESRLYKTGD LARYTEDGFI EILGRSDDQV
KIRGFRIELG EVEAQLTRLD GVREAVVVVK QDGPSQKKLI AYVLCDGLDV AGLRREAARH
LPKHMVPSAF VIMEQFPLTQ NGKVNKRALP EPTAEAIPHT EFVGARNEKE QILTEIWQQV
LKADTVGIHD NFFELGGDSI LSIQIISRAK RAGLHITAKQ IFEFQTIFEL AEAAAELSQY
VQTEQGMLSG DSGLLPVQRW FFESLPADAH HFNQSVMLSV DAEISLQSLK DAWEAVLYQH
DALRMVFSQS DDLRWEARFR NFEHIETFLN SVFEVEDLSG LSHDAVTGRL EALANQAQAG
LSLNGPLVKI VYFNLGDQQA ARMLVVIHHL IVDIFSWRVL LEDLQTALAQ VIAGQRPDLG
QKATSVRQWA MALYAYANSE AMHDELQYWR ALAHQKYAKL SSDRNEPNTV ESVRVLEASL
TTAETRSLLT ETHGAYRTEI NDLLLTALAR SLSDLLEGDT RGQNETLLVE LEGHGREYLG
DHIDISRTVG WFTSIYPVAL PVSDWSLQSE ASSSLGAEAI GLAIKATKES LHAVPNKGFG
FGCLRYLSSS EETRRELAKL PRAALSFNYL GQLDQVQQED GVIRRAQEHP GAEISSKGER
SYAFEVSGRV LDNTLTMAWR YSAGLHDEAT VKAFADRYMA ALRALIRHCQ TADNGGFTPS
DFPLAKLKQD AIDRLFPGRL PIEAVYPLSA VQEGMLFHSL YEPGSWVYFD QINVPFHGKV
DEEAMFAAWQ QVIQRHAILR TGFLWEGVET PLQVVYETVE PQISRYDWSR LSAEEAQEKL
QRYLVDDRNL GFNFRKPGVL RFSWIRMPTE SKTGDETHQF LWSFHHILLD GWSLPIVFGE
LFAAYDALTA GTQQKLPKAP SYQSFIAWLA RQDRHAAEAF WRAYLQGFTA PTPIPVRNSA
AVVRHKLDHL DQHADRYREK EVVLGGNMLA RLQEIAKQHR LTLNHIMQGV WAVLLSRYSG
ENDIVFGTTV SGRPADLPGV EQMVGLFINT LPLRLPVEAE KSFIGWLQKI QTGQVDLKRF
ESTSLVDVQQ WSEVGGKQAM FESILVFENY PIDDTLEQSQ ASLRIGHVEA FQQTNFPLTL
IGIPVKDTLI VRFSYDSIQF EEPVIQRMLG HIAQLMEGVS RQPAAPIREL PMVTAAEVEL
MTQSWNRTAR DIPEDKTLGE LFDAVATRHP NINAWSMNGR HVSYAQLQSR ANRMAAYLVS
CGVSAGDKVV ISFERSIEMI VGILGILKAG AAYVPLDPAY PEDRMQYMVT DTVAPVIITA
EAFAKRFEFA VTSGQSRVVV WEEISERLAR MPEVQTTIVA PGGGDSVACV IYTSGSTGRP
KGVLLPQKGL TRMVVNTNYW ENSPGEKLTH AASLSFDAAS FEIWGALLNG LTLVGIDKDT
VLQPEKFAQV LQQEKPEHVF VTTALMNLIS RQVPDVFANT RYVFFGGEAS DPMQVRAILT
HPGRPQHLMH MYGPCENSTY STGYDIPEVL PGATTVPIGY PVANSTLYLL DNDRNPVPIG
VPGEIYVGGT GLAHGYLNRP DLTEDAFLLD PFSQEAGARM YKTGDLGRFQ EDGALEIIGR
ADDQVKIRGF RIEPGEIENV IAQLPGVQEA CVLARQDEPG KAKILVAYLK MREGVVPNVV
ELRARVRQRL ADFMVPSAFV FLDAVPITPN GKVDKKALPK PAPEAFVTQD FVGARNDTEV
ALTEIWCEVL EIERAGVYDD FFELGGHSLV ITKLASRIKD RLAIELPLRT LFEVPTIAGL
AEIIQSLNWS PDADANSDTD EEDFEEGTL
//
