ID E1W038_GLUAR Unreviewed; 1091 AA.
AC E1W038;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=AARI_30390 {ECO:0000313|EMBL:CBT77241.1};
OS Glutamicibacter arilaitensis (strain DSM 16368 / CIP 108037 / IAM 15318 /
OS JCM 13566 / NCIMB 14258 / Re117) (Arthrobacter arilaitensis).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Glutamicibacter.
OX NCBI_TaxID=861360 {ECO:0000313|Proteomes:UP000006878};
RN [1] {ECO:0000313|EMBL:CBT77241.1, ECO:0000313|Proteomes:UP000006878}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 16368 / CIP 108037 / IAM 15318 / JCM 13566 / Re117
RC {ECO:0000313|Proteomes:UP000006878};
RX PubMed=21124797; DOI=10.1371/journal.pone.0015489;
RA Monnet C., Loux V., Gibrat J.F., Spinnler E., Barbe V., Vacherie B.,
RA Gavory F., Gourbeyre E., Siguier P., Chandler M., Elleuch R., Irlinger F.,
RA Vallaeys T.;
RT "The Arthrobacter arilaitensis Re117 genome sequence reveals its genetic
RT adaptation to the surface of cheese.";
RL PLoS ONE 5:E15489-E15489(2010).
RN [2] {ECO:0000313|Proteomes:UP000006878}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16368 / CIP 108037 / IAM 15318 / JCM 13566 / Re117
RC {ECO:0000313|Proteomes:UP000006878};
RA Genoscope.;
RT "Complete genome sequence of Arthrobacter arilaitensis (strain DSM 16368 /
RT CIP 108037 / JCM 13566 / Re117).";
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; FQ311875; CBT77241.1; -; Genomic_DNA.
DR RefSeq; WP_013350346.1; NC_014550.1.
DR AlphaFoldDB; E1W038; -.
DR STRING; 861360.AARI_30390; -.
DR REBASE; 28310; Aar117ORF30390P.
DR KEGG; aai:AARI_30390; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_009503_1_0_11; -.
DR Proteomes; UP000006878; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CBT77241.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006878};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBT77241.1}.
FT DOMAIN 311..499
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 686..1035
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1091 AA; 121051 MW; 1E86AE3FDFF35105 CRC64;
MVKIADLVEQ YGALAKDLLN GPGEPEAALS QPVTELIIAV SNDLLQRKTV MHREVREDSG
TVRPDYGARV DGLMTGHVEL KKPGTSLDPS TYAKTSHNAR QWQRLSNLPN LLHTNGTDWR
LWRFGELIAD STLHTPSLAT HKGKLTAPAS FLPLITDFLT WTPTPITSVG RLVDTIAPLA
VMLREEVLES LKADRRFAKA NNIDPGLRPF IGLHRDWRAS LYPRATDEEF ADGFAQTVVF
ALVVGLSEGI ELEGLKIPEI ASRLKANHTL LGRALDLLTE HVAESTVGLA IETIVRALSA
ARWQHISQGR QDVYLHLYEH FLSAYNPERR KQSGSFYTPV EVVDSMTRLT DEALKKYLNT
PEGLSADTVA VIDPAMGTGT YPLSVLRQVA DNSSKYGQGA VSDAVTSAAQ RLYGIELQSG
PFSVAELRLT QAIRDYGGSL PDGGLNLYVA DTLEDPKSGS SRQLSYTLQL IAEQRQRANK
MKVETPIQVC IGNPPYKDKS EGLGGWIELG DPNRPNTPLD DFRLPGNGKF EYVLKNLYVY
FWRWAMWKVF ESTPASHHGV VCFITATGYL NGPGFRGMRQ WIRENTSRGW IINLTPEGKQ
PPANTAVFNI ETPVSIALFI RDQANDPTAP SEIKYTELHG LRKEKFGALD KLNLSDASFT
LAGSDWTDGF VPAAGDEWTA FPALNDLFPW TAPGIKPNKT WVYNPNKEIL EQRWNDLILE
DDKELKAAKF KETSSTGLHL TKKIPLIGSD TEQNTQDAFD SVAWPTQPSI VHVGYRSFDR
QHIIADSRLL HRASPDLWAA RSKDQVFMVE QHAHEPGRGP GIMLSHLIPD MDYFNNRGGR
VLPMLNPDGS PNVALDLLDT LSEQLGADLT VDDLFAYVAG ISAHPGYVER FSDEVKYGAN
RVPITSDLEL WSKTVDIGRL VLWLHTFGER GVAPLGATSI LDHVTTGALP SYDVAVSSAM
PETATYEPLT QTISLGSGQW SNVDPRVWSY AVGGREVIES WIGYRRKKPK GKRTSPLNDL
VTTNWPSQWS REFSELLAVL THLVHLEEQQ ADLLEQVLDG PILSVSELED MGVQWPKVPK
DRKPRMAGDL F
//
