ID   E1Z963_CHLVA            Unreviewed;       735 AA.
AC   E1Z963;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
GN   ORFNames=CHLNCDRAFT_51004 {ECO:0000313|EMBL:EFN57461.1};
OS   Chlorella variabilis (Green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC   Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX   NCBI_TaxID=554065 {ECO:0000313|Proteomes:UP000008141};
RN   [1] {ECO:0000313|EMBL:EFN57461.1, ECO:0000313|Proteomes:UP000008141}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NC64A {ECO:0000313|EMBL:EFN57461.1,
RC   ECO:0000313|Proteomes:UP000008141};
RX   PubMed=20852019; DOI=10.1105/tpc.110.076406;
RA   Blanc G., Duncan G., Agarkova I., Borodovsky M., Gurnon J., Kuo A.,
RA   Lindquist E., Lucas S., Pangilinan J., Polle J., Salamov A., Terry A.,
RA   Yamada T., Dunigan D.D., Grigoriev I.V., Claverie J.M., Van Etten J.L.;
RT   "The Chlorella variabilis NC64A genome reveals adaptation to
RT   photosymbiosis, coevolution with viruses, and cryptic sex.";
RL   Plant Cell 22:2943-2955(2010).
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   EMBL; GL433839; EFN57461.1; -; Genomic_DNA.
DR   RefSeq; XP_005849563.1; XM_005849501.1.
DR   AlphaFoldDB; E1Z963; -.
DR   MEROPS; S09.015; -.
DR   GeneID; 17357250; -.
DR   KEGG; cvr:CHLNCDRAFT_51004; -.
DR   eggNOG; KOG2237; Eukaryota.
DR   InParanoid; E1Z963; -.
DR   OMA; SWHIAGT; -.
DR   OrthoDB; 307182at2759; -.
DR   Proteomes; UP000008141; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR11757:SF19; PROLYL ENDOPEPTIDASE-LIKE; 1.
DR   PANTHER; PTHR11757; PROTEASE FAMILY S9A OLIGOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU368024};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008141};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          2..413
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          518..732
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          424..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  78654 MW;  6DC8C4EC0A24C61C CRC64;
     MLQLVPSSQV SAPERLGAYE YYVQQMPGRP HPCYMRRVAH VAAPRSLSFS STSNSRFSGG
     APGGEVVLDV NDLAAVHGEY VQVGQVKLTR CGRHVAFTLD AGDGSEAFGA FTRDLRTGAL
     RHLATVGSVV SLEWAADGRT LLCTQPNGLG RPWRVLGADA AAAAAGDGAA SWPLFEEEDE
     RFFVELGRTK DWSFLTINCN SKASSEVHLL PADLRGSGTA VAVGPRLVQQ RTPGLEYFVE
     HSCGQLYILS NARGETNYAV FRVPTSVPDL GQVHWQRVVG EREAGGAMED MDMLEGWLVL
     YLRRHGRQQV AALPLGHGLP LVAQSISETT TAAAAAEEDP AASAGAAAGA AAATVSALAQ
     APAEVLRVAP LPDWALSVVA GANADYYSSH IRLLLSSPVH PEAAFDWHLG REQLAEWRGL
     APLGGQHRQQ QQERQQEQPP GQQHCDTAAT MPLSQQQSLS PPGYKWQQLW ATSPDGTQVP
     LTVAHAAALA PPAPCPCLLV VYGAYGHCLP ADYLPERIPL LHRGWVLALA HVRGGGELGR
     RWHAAGRGGA KATSVDDLEA CLDHLVSAGY TAPGMVALEA HSAGGLAAGA LLNRRPNALG
     AALLEAPFVD VLSAMCQPDL PLTRHEYEEF GDPGDPHQFN QIRALCPYQT VRQAAYPPVL
     LTCSQQDMRV PYWGPLKFAA RLQAAAREGQ AGRVQGGPIL LLPDGQAGHF VHERDLFQTK
     AQQYAFLVTA IEGRL
//