ID E2AB89_CAMFO Unreviewed; 633 AA.
AC E2AB89;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=U4/U6 small nuclear ribonucleoprotein Prp3 {ECO:0000256|ARBA:ARBA00016514};
DE AltName: Full=Pre-mRNA-splicing factor 3 {ECO:0000256|ARBA:ARBA00032955};
GN ORFNames=EAG_01105 {ECO:0000313|EMBL:EFN69365.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN69365.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-
CC U5 tri-snRNP complex that is involved in spliceosome assembly, and as
CC component of the precatalytic spliceosome (spliceosome B complex).
CC {ECO:0000256|ARBA:ARBA00035603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GL438234; EFN69365.1; -; Genomic_DNA.
DR RefSeq; XP_011254826.1; XM_011256524.2.
DR AlphaFoldDB; E2AB89; -.
DR STRING; 104421.E2AB89; -.
DR EnsemblMetazoa; XM_011256524.3; XP_011254826.1; LOC105250432.
DR GeneID; 105250432; -.
DR KEGG; cfo:105250432; -.
DR InParanoid; E2AB89; -.
DR OMA; KNHEMRN; -.
DR OrthoDB; 5489218at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR013881; Pre-mRNA_splic_Prp3_dom.
DR InterPro; IPR027104; Prp3.
DR InterPro; IPR010541; Prp3_C.
DR InterPro; IPR002483; PWI_dom.
DR PANTHER; PTHR14212; U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED; 1.
DR PANTHER; PTHR14212:SF0; U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3; 1.
DR Pfam; PF08572; PRP3; 1.
DR Pfam; PF06544; Prp3_C; 1.
DR Pfam; PF01480; PWI; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Ribonucleoprotein {ECO:0000313|EMBL:EFN69365.1}.
FT DOMAIN 10..70
FT /note="PWI"
FT /evidence="ECO:0000259|Pfam:PF01480"
FT DOMAIN 264..475
FT /note="Pre-mRNA-splicing factor 3"
FT /evidence="ECO:0000259|Pfam:PF08572"
FT DOMAIN 498..619
FT /note="Small nuclear ribonucleoprotein Prp3 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06544"
FT REGION 77..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 633 AA; 72551 MW; 99EEBB0FD3B79AC4 CRC64;
MSYLTRKEVD EIKPQIEKAV HKFLGFSEPA IVTTAINCIT SGYDKRKTAD KLSALLEDKK
ASKLTEKIFT IYDDTKAAQK NKKRPHSEDK DKEKDAKKSR FKDDEAKNEK TAEPQLSADK
IRQMMANAQK EIEERKRALK AIKQEDVSAK PLFKGRDTLP TVGSMYNQGL LSKTDSDKAR
KIAALQAQIR NKLSSGLLAN INVPDKPTPL ILDESGRTVD ITGKEVQLTQ VVPTLKANIR
AKKREEFKAQ LQESKGPEEI QDTQFFDGRI GVKPAMRGKR ALKFHEPGKF QQLAERIRMK
TQLEKLQNEI SQIARKTGIS SATKLALIAP KTEALSEDVP NIEWWDSVIL INGYPNENES
TTIKNLAITN LVEHPAQMRP PTDPLKPIYM PVFLTKKERK KLRRQNRRET WKEEQEKIRL
GLEPPPEPKL RISNLMRVLG TEAVQDPTKI EAHVRQQMAK RLKAHEDANA ARRLTADQRR
EKKARKLKED TSLGVHVAVY RIRDLVNNAS KKFKVETNAK QLYLTGCVML FRDCNVVVVE
GGIKQQSKYK RLMMHRIKWE EDIVKDNDGN DVPNRCVLVW EGTSKQRHFG EIKFKVCPIE
KMAREHFKKH QVEHYWDLAY SGAVLDNTDE VRS
//
