ID E2AF18_CAMFO Unreviewed; 1657 AA.
AC E2AF18;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Double-stranded RNA-specific editase Adar {ECO:0000313|EMBL:EFN67973.1};
GN ORFNames=EAG_10511 {ECO:0000313|EMBL:EFN67973.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN67973.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; GL438984; EFN67973.1; -; Genomic_DNA.
DR STRING; 104421.E2AF18; -.
DR EnsemblMetazoa; XM_011258655.3; XP_011256957.1; LOC105251689.
DR InParanoid; E2AF18; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF12832; MFS_1_like; 1.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1072..1138
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 1218..1254
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 1331..1653
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1657 AA; 185325 MW; A9F9B12F9557E40C CRC64;
MQNYGHEDYG YGASDDASNM QSSRALPQVP GARPVVDPQA EGEVDPSMYP QPKEATHKIR
GKSDILEYLF GAVDQELLTV KTFYFFFYSA FGSLFPLMGV YFKQMGMNAG QCGLLIGLRP
FIEFLSAPFW GSLADRWQKG KLILLASLSC WIIFTLPLGF IQPPPTACMV KDPNDTYYLE
ASSREQRIVK RSTNLDELYY PQNKEEYLEV ASNVVFERLR RNIDDNEILD YTKNPNSAKE
TNMFETSFNI VKNDITNFDN DDSTAYDLEN NRVKRQISLT NKNLRYLTLE DNVDLDSKTI
DLESLQKKNR PADILEYKHF LKNEEIIDRA VPKKAHVHTK TRVKPPPEKI MVKRDVEKKL
SLLNENDINI DNNEEETGRS MDMPLIRNRR SVRTLHGSLL TQNQLSPLSV TYATNYNERE
NKGWVKPLFS SIVYRLPDIQ KTFFLLLLLV VVGEFFSAPA ITLADSAVIT LLGEDADRYG
HQRMFGSLGW GLAMFFVGIA LDHSTAFPEH PCKPDDREKN YTICFAIFSV LMGAALITAT
QINFKYDFAS AEYPQEVMGP AEPTQEEKLQ SQLSQQLNLP GLQDSSAAVD PKPQPPEGKT
KMFAQTTREI PEWVTVLKQF KDLKCASFLF VAWFMGFGIG LIFTFLFWHL QDYGGSPTLF
GVASVINHIS EIFAYFFSFK LIRQIGHVKV LCLGLGGNIL RFLYISWLRN PWWVLPFEFI
QGITHAAVWA ACCSYIAHNT PSQLRSSAQG VLQGLHHGLG RGCGAVIGGM FVAAYGTTTT
FRAYGVICSV VLAIFIFINF YRKDTGFVSE LPQTEDPHQV AEATHLAPHG VPSNAIPRAL
SSTRLHELAN QDAGYGATYQ TAGGNLAVPG ANGGPGNPTN PFLNGGGGGE GGYNYGMTGK
GEDEYIRRSF QIYNEVVGRE FDVVKPTIQL HAQQPCTNPF HQHDYDCLSR KGLLKKLRFL
INHMDLRTIV KCFNRGLFAD DPDIICVGYN EIVRRGLHNT VYVEAIVNKY KKLYECNPPM
ISANGNTLLD NSQSGHTTLM GQGNSPKSIL KRTSEVDLED VSSAKKRHKN PQPKNAVCAL
NELKTGATYK VVGQTGPTHA PIFTIAVQID GQTYEGKGRT KKMAKHAAAE LALRNIIQFR
NTPEVHQAIN TCQPVVPLEP DFTSDVTERD NHLVNAFKTQ EPKNTNKFLD KGPVALINEL
YPGVIYNCIS DNGESYAKFT ISVTIDGETF EGTGPSKKLA KAAASKAALA KLRNVHSSSF
CIPLPVRILP NFSNSAHWQE QMTLPQMLAD RIGKMVNQKF SELIQSKPQH ARRKVLAGIV
QTKGSDAELI CVTTGTKCVS GEHLSVSGGA VNDCHAEVVA RRCLCEYLYK QLELHTEDKS
TESILEPIKK GFKLKQGIQF HLYINTAPCG DARIFSPHEE NESIDKHPNR RARGQLRTKI
ESGEGTIPVK SNEGIQTWDG VLMGQRLLTM SCSDKIARWN VLGVQGALLS HFIEPIYFHS
IVLGSLLNPS HMYRAVCGRI ENTIQGLPPP YRLNKPLMSL ITSSEVRQPG KAPNYSVNWT
IGQSEAEVIN CTTGKDELGK PSRISKQAFF RRFFSLLSKL PTIDDVDENR CRHYLDAKSS
VQDYSLAKRQ LKDAFVRAQL GSWVKKPIEQ DMFEVDI
//
