ID E2AHF2_CAMFO Unreviewed; 1238 AA.
AC E2AHF2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Protein toll {ECO:0000313|EMBL:EFN67144.1};
GN ORFNames=EAG_14329 {ECO:0000313|EMBL:EFN67144.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN67144.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL439518; EFN67144.1; -; Genomic_DNA.
DR RefSeq; XP_011258081.1; XM_011259779.2.
DR AlphaFoldDB; E2AHF2; -.
DR STRING; 104421.E2AHF2; -.
DR GeneID; 105252428; -.
DR KEGG; cfo:105252428; -.
DR InParanoid; E2AHF2; -.
DR OMA; WSTMSLE; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 24.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1238
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003157140"
FT TRANSMEM 1009..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1063..1198
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1202..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1238 AA; 141267 MW; E1D8E38612F2704B CRC64;
MRGSPAFLAI LLGTIFGVLG ASLSKALRYK APDECKWITT GDAEDDVSLV CRLRTINSEL
ENTNFSVIQP QHTVRLRLEC SDALFYQSSL SAGSFRPLVE LRELVIEYCK IGNLSDDAFK
GLRELRNLTV KTHNTDWSAM ALDVPAGAFT DELRQLEKLD LGENNMWSIP EGALCPLVNL
EILNLTRNRL RDIASFRFNA ATRCLANLRE LDLSNNSIES LPSAAFSGLT RLHTLDLRCN
AIGFMADRAF EGLSSLAILR LADNRLASLP PELFGDARDI QEIHLRNNTL SVLPPGLFND
LEQLLVLDLS HNELTAEWVN AATFSNLVRL VVLDLSSNHI ARLDPTVFRD LYSLQILRLQ
ENLLEGLAEN TFSALYNLHT LVLSDNRLTI VDATTLSGLY VLSLLSLDNN RLHTIHPSSL
RNVSSLQDFH LNGNRLTSVP DALKATPLLR TLDLGENLIS EIPSGTFDHV AQLYGLRLTE
NHIGNLTKGV FDRIKGLKIL NLSRNRVQHI EPGTFDENLN LQAIRLDGNQ LIDISNLFAK
LPNLVWLNIS DNRLEWFDYA MIPTGLQWLD IHSNEIRELS NYYEIEGQLQ LSTFDASDNK
LSEITGNAIP TSVEVLFLND NLISKVQSYS FFKKPNLTRV DLKGNQIRNL EPYALRISAV
PPDKPLPEFY IGDNQYLCDC TMEWLQRVNR QNQTRVQPRV MDLESIYCKL LYDREHVFVP
LVEASHSQFL CKYDTHCFAL CHCCDFDACD CEMTCPYNCT CYHDQSWSAN VVDCSNGGHA
SRLPEQIPMD ATRLYLDGND LRVVSSHAFI GRKKLKVLFL NSSNIEIVQN RSFNGLRDLD
DLHLQDNRIR ELRGHEFEGL DALRHLHLQR NRIVVIGNDT FASLHSLRLL QLQNNRLTNL
ALWSLPGALE IRLAGNPWSC ECDYLRTFRE WTHEPNVRVL DASALRCVYN VTEFETFGDE
VFADDEFGFS VSARVNGNES ACSDAINVDD DAHRNYTKTI IERQILQDYL PLLVATLASS
LVVILLCLLA FVYRHELRVW FHSRFGVRIF YRGNEIDRDD RDKLFDAFVS YSSKDEAFVA
EELAPVLEMG NPSYKLCLHY RDFPVGSFIA DTIVQAVESS RRTIMVLSEN FIKSEWCRFD
FKSAHHQVLR DRRRRLILVL VGDVHQRDLD PDIRLYLKTN TYLQWGDKLF WEKLRFALPD
VPNNQRTTQQ RTRQQPPPVR RQHNNRTSNG SRTVSVHI
//
