ID E2ALD6_CAMFO Unreviewed; 3422 AA.
AC E2ALD6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:EFN65741.1};
GN ORFNames=EAG_16049 {ECO:0000313|EMBL:EFN65741.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN65741.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL440604; EFN65741.1; -; Genomic_DNA.
DR STRING; 104421.E2ALD6; -.
DR InParanoid; E2ALD6; -.
DR OMA; MGAPPEF; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2648..2757
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2762..3062
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3228..3269
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1042..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1957..2008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..2004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3422 AA; 384529 MW; 1D38A2E40C11FEAA CRC64;
MSTVSVNKLQ ILWDHFIHAE PQSYEKSSWL DIFLAEFLAQ IKEGKDIKDV LSFCSVGGGG
VSTLVACELL SDVHELCGKR NDGSELVSLR KYLVQDRGWR YLAVLHLLDV RGLSCGRELV
TLLVALYPVA FQEGTTDSKT NLFTTSQKSN GESIVESSTR NQYVKFHCND DIVDMIDIVL
HTKRKTTKDF FHETDAPLRG RSARRRSIAD AAKSRQSINH KRIKSPLILK SRRNTSENAT
SSESELLTDG INTTRSLTLK IRLNPMDFEY FTSIVRSDEE QKWQAELYEL PPRPVRKTPC
DYIDERIQDV LNAKISNFEI SLLIIQLLQG LRDYDTPAEQ TPAVQVLKFA LDTLWSLQFG
IDSNNLSSTE CVTLKAAAAR LMLTALERAL RADEPTTAVI QNGLLPMTLR LLEDACSKPI
NVLEPEEGSL LQEFIFATIY GIVTFLYCLL HQRGGNVDKL SDFLELFRLF IESQDGKLVE
RTIFAIIDLR TIDATKSIVR AKKIIDMIGA LTSGLKRIRR DLSHATQCHR TKHRSCIDNI
QSYHHSNVFG IPYSQSVVNT ADKQMCCISS LFATLMSLLK KSHLFASELQ VRLIKITTAA
GTCCCFPPKV LISSVVTFLK KCDFSTYASA VAFLERIFFK ELGAYAMTDA CSTCVRPANY
SWDFLEMYVD LLCPSDPKLC YIVMAHLLQV TSGSRFHVRE QLLLRVFYPA FLRAKECYTI
NNDDVTAKFL LQSCMSVMSC LIVNAHMCER FMEINGLREI LPLMANLAFT RSVYALLEVT
VTMEIWKMRD EKFDNLESIE MPIATRSLFE SLDRETNELL NCLRCFEKPK IEENAEENKN
TFDKRSDNQN VDLSPVKKLK IDETTIKSLD DVTTLPQLPE SDIHREQLEN KTDTINTVVI
SNSFKKLYNL IEQVEVYDAE VSFEKFNLYR ASIAWRATAG VALCSPKFRT ELSTHSVSKK
SLRLFRLLTI GLATDSIEDT GKSAHKLFEA LITCCLISPF YDCDIIMELR ETLMSTGMKL
GRGIAVIVNA ILKVSMLKPA QENSIPQQPR PRLPTLSLEN PPDYSAEDSS TGEYITADDG
YEADVEVPEK SPNNSTSKKS SPLGLVIEPR GHANAHPALC SLAIDLLIHF SQQSLDLEKG
SIITGGLRRI AGTCRESVSS CAALAASGTI MKILNGFKNV FINNDPRYRD LQHAALEVFT
LLATQSISSA ELVEYMSFFK TERPPLLPLL EPLYHLVLVA RPQPNFILSF PVHCDIKTSP
KTEQHKNLEK AENLVKNFRK KHLAAGICSP WSVHAICLPV GPELAWPVWL HGCSASMWIR
VERGMSIGSR ATIYNTSPLL DSDNESLSDW GILSDNWNRQ EKLDLIFDLF SESLVVAGSV
SPPTPTSIIH LMSIGFESLV LEMWLDLKSD KLILRLTRPD DKMNRTISET SINNMLSCGH
WHHLTLNFKD TVLNKRSAVV DVTLWVDGWK EINAQLPFDG LLMRKPGTTC VLLGQIGSSS
IGAWYFGNLM VFRCPVFTKE RALYLTSLGP NYTNLADCIL NTVKPDFAPL ITSGALNGVC
EVKYEESKFD SSRRKSYDDT YLKHAVETVV SESKVDWDAV MDATNSHLGD LQDNLLLSYE
AQNPNIVHLY PQAITNPAVI VGNIFPGQPG FRIISAPEHR VSQQPPLSIP PIVSTRLENQ
QYRGLIPAAI LVGGVPVFLY LFARVVELNS TEEEQALALS IVLHLVRSDS ELLNQYRLDG
GTLLVLRVLE SSRCHAGRHI LKAMLDAACD SSIIIRDIGS NHPVSQNCEA VITDPELIKA
ALTAWRAWAK YDTLNLLLQT LLLLLRDQHS QREFNASQLN RVGIVDTILT LCKEHFMYEI
NEEVNAVLDS NTGIAIVELM RALMGAPPEF AHLVAITDYL VLVHQASETY VTHSRQNIYF
MLPQLRETKT NLKKSDNSSI SSNDSISLME NSKLNKALTN EQIQKTRSPK KKNRKNTPMD
NTSGGEDSGI AASDGSTPQS NERQSTYSDE KRACQGLVCE GLLLLLRDAV RVLPDCQVGS
VLKHVLRAEL LLVLANDPDN RVRTALIKVI QTYLQRASDE EVNKFIKQKY FMHLGNQIAL
YPASDSVVIA LENLAARSPT LAAMSMLMAI IAKTSNSDSS IVRPLILFIT DVIVKNINAL
KVLLEQGLIE SLVQGLVGTA YKSNSMSLHR DIHVLFVTIA TKLLELPGSH QIQAILDLHV
ILDYMEISEK LRCCTSSIRT AVRDAQVALF DGELDALVTK LSNPSGFRLR STASYLASAS
YFTSVLTTSG EQSDHGSHSS SYGSFHASSS SVLREPGKGE LNDRFRIIVT RAVEFITTAD
TSPSVNELQL TRRLFSILLH GLCSPLEKKN HWSNTWSIRP ALRKYTARIM IWLLEPHQSI
NTRMYAIRSL MEEPRAREIL SCILEVHPQI EQKFTVFFWD LLQKRDEMPS VDARVCAELR
EALRVWNLAK GIEQANPEVW NDELALLRRD MFLDRDICID NYPAVLRIGK RFDALAKQLI
ESAMNITRSV VEEQNRERKV LMEQLKHMRA LQAQTVARWR DIAKRLTHEW APWYFSDSYP
KNWELDPTEG PARVRIRLQR CHLNIDKRFF LPEHQNNLDS SNIEMPLSYL FTSTHEDANT
VALIERLHTS EKIRKMSQVK VVTPRAELAG EVLIGETCVY FVPDNPDMPL HTDIALGGFD
LAVTGGTAWR LEDIRELHRR RYQLQERAIE IFLITGRTYL LAFNSSKERD EFATELSACN
LPRRIPGDDL GEALTLWRSG ALTNWEYIIC LNKLAGRSYN DLMQYPVFPF VLADYVSDKL
DLNDPKIYRN FKRPMAVQDK KNEQHYINNY NYLKQTLTEG LNLIALNQGP FHYGSHYSNS
GTVLHFLVRL PPFTSMFLCY QDNNFDIPDR TFHALATTWR LTSCDSTTDV KELIPEFFYL
PEFLLNFEGF NFGVRQNGNK VGDVELPKWC GGDVRLFILA HRAALESDIV REVLPYWIDL
VFGFRQTGKP AVEAINVFHP ATYYGFDVEQ ISDSLERQAW ETMIRTYGQT PAQLFRTPHP
LIQNLGNVTL SDQTLQVIEG VSGIKWGNYV GAPGNKPVLC WKLKHKTPLA SLIPLATGDV
FGLPNYTTLL LGYTKEKGGS MLSNMSVLGA ALASWNGTDG IARLKCKKEQ PPKPLIKSSG
LDPITTLGST PDCGQLWIGH LSGRITAHTY IIGITGKIEF SLAPAITLLA HRSRVTTISL
SRAFSIACSG DANGVIAIWD LNSLTYVRSI VCDQGYTIHL LCISETLGDV AITYEIPRSE
DNVTADRSEL RVYTINARAV GSISSKRRVT ALCYSSAPEG VSVNVIATGL DNGIIRLWSS
WDLQLVREIS NNLRDSCAII AVVWSLDQHH LYAVTEDSTV LIWEGSKRLS NGTPKFVNLT
SF
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