ID E2ARF0_CAMFO Unreviewed; 2203 AA.
AC E2ARF0;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Protein still life, isoforms C/SIF type 2 {ECO:0000313|EMBL:EFN63959.1};
GN ORFNames=EAG_09572 {ECO:0000313|EMBL:EFN63959.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN63959.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL442063; EFN63959.1; -; Genomic_DNA.
DR STRING; 104421.E2ARF0; -.
DR InParanoid; E2ARF0; -.
DR OMA; HEPQCPH; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000311}.
FT DOMAIN 38..156
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 1023..1136
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1308..1375
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1391..1467
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1602..1796
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 164..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2098..2117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2158..2182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1570..1595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2031..2050
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2051..2066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2067..2089
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2101..2117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2203 AA; 249369 MW; DA2C8A0F92D655E8 CRC64;
MGNKLSCSCA PLIRSKTYRY EDSPWQAGAR GGMGGGGGRR GDTGHLLRLW AEVFHVNSSG
AGTVKWQQVS EDLVPVNITC IQDSPECVFH ITAYNSQVDK ILDVRLVQPG TRIGQASECF
VYWKDTVTND TWGLNFTSPI DAKQFRECCS PSFKISRKAS SSYSLKLEPP NKQKIKTRRK
PLSTPASPSR SREPQCTCMT PEQFARLRSQ DPRYRSPCGP STLPRTMARS TEMEMTPGRD
KITAATSSAS LYDNVNNPSA TPGKTPKTAD SAKQKDKQNE TCQTTPKTAN VGIGTVTIDS
PDEKGSTISP KKSQKQSQDS STQQNGTEML KSEGTQAGGT LQSKLLRKEQ LHHTKSADYT
ELEMQNGNLF NIVNNNHGHR SKSKSTDDMR IENAQNGGIS LDPNTLKRML KPMPSIDSPV
TSPEMTRKRH SHHSYHYHPS NNNQKYMMQE VDNENYAHPY RAPYNNKFQG SRSVHDMSRQ
YPGGRSRTYL DSERNRCTGD MSPPSDNVIF DNQCYATTPS SSNGNSDMEQ PNHCNSRRCN
GGQTYQQQNM QSVSTPGSPT SRLLLEYEMH LRNTLAKGMD AESYSLRTFE ALLTQSMENL
EFAENIPLNV QRTPHVSRRR SNSNKSSTLP LSYRYCNERQ NSKDRDGYYS DRNEMVREKR
ERDSDRDRGY LSDYNSRCAS CIGESARAQW FRHSDGWQSG SSTLGSGASS SINPGYSGYK
RESPWDSLPS LRHEGSLNDS GYKSNRTDSL EQRGTFDRQD SVRSDYMSDR DGRYGIVQQA
SLESTDSRLC YLTSSELPPA EEQRIMVEPR WSIKCTNSTL DLLDPSDDSY TDLKTQHRRR
CWKYFCWCRR HTISVICINE SRKLYWFNCR NVQEKVTYGS GEGYYHKLLR LVNGALNTWA
QRYIDGLSVA RREIMLKING SADNNMRLLK EGCYCHYHPH MTADACNADF LRRVVSFWAG
ESLRGIRERL RGMTNITKKM SDDDRMSLTT AVSDDDDGES VINSPYRGKQ TGTAAASFNC
TGAVRKAGFL SVKKWLLRKK HQIELARKRG WKGYWVCLKG TTLLFYPCDS QESRAMEAAP
KHLIIVDGAI MQPIPEHPKR DYIFCLSTAF GDAYLFQAPC QVELENWVNS IHSACAAAFA
RHRGKTGTLH LLQEEIFRLE KAIESDHKMK HMADLQQSVV SDVDTKQQIN NQIVQWEENL
ERLHCEQFRL RCYMASLQSG ELPNPKSLLT HVSRATKQTL NKLGVFTVSS FHAFICARSP
SLLNNLLAGR GATKRRPPLL SRSNSGSSRR SLQISSRDEE KSVKVSVPEN QVRSSGHRLV
SVFLRDAMTV EEFLASACTR KNLNPMEHFV RVKKRRDMED HNYFVPHRTD LIETYLHTHE
IVEVCAKILY QVELQRNTLE QMWGFSVEAE LIENSDRQDE LCCYVSRVED KSVAMQNGII
KGDEIMVING AIVSDLDMMY LESVLQEEVG LCMMMRSSRT EPPDLTGIMR VTDDIIESLV
CPPPPTDPPV ISEEMISGLI VPAPGWSKEN IMQDCSAAHM ENSKQTSRTN SFEIENLLKT
AEQVTGICRS PGETRKSSPT GSVVSSHSQA LTPSRQLSDA EKLKKVILEL IETERTYVKN
LNNLLENYLE PLKRETFLSN AEINALFGNI QEIVTFQRQF LQNLDHAIEM EADFNSFDHP
SQFKGVLFSI GSAFLYYVNH FKLYSSFCAS HSKAQKVLHP NEGNQALQEF LQARNPRQQH
SSTLESYLIK PIQRILKYPL LLQQLRNLTD ERSEEHQHLI EALKGMEKVA EHINEMQRIH
EEYGAIFDHL FRQHQKSCKQ PIDLSPGDLL YYGGVEWLNI SDFLGKIKKG LELHAMCFVF
KSAVVFLCKE RLRQKKKLMG VSTKANSSEV EIIRYQVLIP VTEVQVRASS AKDMESHFLW
ELIHLRSQLQ RRSEKVYVLS NSTTEFRNAF LKTIRQIIRE SVRNMSIPST KQNMSHAPMS
MAPRMSTGHV EKFDKQQIGQ AQNGNGSITG TLSKKAMKQQ LLANSHKRKY SHSKQPVEHE
SSEDKDQEDA PVVQQQTTFR SRSKTISDTS SEIKVEMDSG TKSEGEEDSQ AFLGEKKTNL
GRTPNHLTLS TTSTISAGST GSQARLIQSS HQPENYQPIT VKELGSPIWK PRELPSLGEA
TTLPRKGKSA GEFADMSSSH SASRKSLIEI NNCAQQPNFN NHV
//
