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Database: UniProt
Entry: E2ARS8_CAMFO
LinkDB: E2ARS8_CAMFO
Original site: E2ARS8_CAMFO 
ID   E2ARS8_CAMFO            Unreviewed;       945 AA.
AC   E2ARS8;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=EAG_10276 {ECO:0000313|EMBL:EFN63846.1};
OS   Camponotus floridanus (Florida carpenter ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
OC   Vespoidea; Formicidae; Formicinae; Camponotus.
OX   NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN   [1] {ECO:0000313|EMBL:EFN63846.1, ECO:0000313|Proteomes:UP000000311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; GL442170; EFN63846.1; -; Genomic_DNA.
DR   InParanoid; E2ARS8; -.
DR   OMA; HNITDEI; -.
DR   Proteomes; UP000000311; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000311};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      7     25       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     45     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     78     97       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    217    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    379    400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    412    430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    494    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    581    608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    810    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    869       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    890    923       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5    283       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      378    616       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      771    924       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   945 AA;  107168 MW;  61190F2BA6042BA0 CRC64;
     MSLRRPFEWL ILMTIFANCV ALAVYTPYPF GDSNLTNQYL EKIEYVFLVI FTVECVMKII
     AYGFVAHPGA YLRNGWNLLD FTIVVIGMIS TVLMMLMKEG FDVKALRAFR VLRPLRLVSG
     VPSLQVVLNS ILRAMVPLLH IALLVLFVII IYAIIGLELF SGKLHKTCRH NITDEIMDNP
     VPCGEMGYQC SNIGPEYYCS KQFWEGPNYG ITNFDNFGLA MLTVFQCVTL EGWTDVLYNI
     EDAMGSSWQW IYFISMVILG AFFVMNLILG VLSGEFSKER EKAKARGDFH KLREKQQIED
     DLRGYLDWIT QAEDIEPEID ESKQDGKTKQ QNEIESTDQL EGDEEGIQQE SVWKKKKRDL
     ERVNRRMRRA CRKAVKSQVF YWLIIVLVFL NTGVLATEHY DQPHWLDEFQ EITNMFFIVL
     FSMEMMLKMY SLGFQGYFVS LFNRFDCFVV IGSITEMILT NTRVMPPLGI SVLRCVRLLR
     VFKVTKYWRS LSNLVASLLN SIQSIASLLL LLFLFIVIFA LLGMQVFGGK FNFSESEEKT
     RHNFDSFWQS LLTVFQILTG EDWNVVMYVG IQAYGGVASI GVLACVYFII LFICGNYILL
     NVFLAIAVDN LADAESLTAI EKEAEEEAEK NKSRSGSPAR DEVSGEAGDD GGEGTGGEDE
     GAGTDLEQDP NETMEDYEAA LDTETSEKSD DMNTHKVRLN IESDEEMEED EEKEGDDQDM
     QDDGQEISAR PRRMSEYNMA TKKEPIPAGS AFFIFSSTNR FRIFCHWFCN HSYFSNVILV
     CIMISSAMLA AEDPLSASAE RNRILNYFDY FFTTVFTIEI CLKMISYGFI IHEGAFCRSA
     FNLLDLLVVC ASLVSMSVST GAFSFIKVLR VLRVLRPLRA INRAKGLKHV VQCVIVAVKT
     IGNIVLVTSL LQFVFAVIGV QLFKVGLSGP DTPTRPQKSS PPNLL
//
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