ID E2B4N9_HARSA Unreviewed; 1390 AA.
AC E2B4N9;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000313|EMBL:EFN89320.1};
GN ORFNames=EAI_07638 {ECO:0000313|EMBL:EFN89320.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN89320.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN89320.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR EMBL; GL445584; EFN89320.1; -; Genomic_DNA.
DR STRING; 610380.E2B4N9; -.
DR InParanoid; E2B4N9; -.
DR OMA; GTCEYEF; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF249; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 130..211
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 262..375
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 380..451
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 616..702
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 727..954
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 29..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1255
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1363..1377
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 154018 MW; 7EF08E1FCCA608DB CRC64;
MHRPPHPHPI TDHRQVNLVF DDTFSQGLTG RPELYQKSNR SSHSSDTSSA YSGSDTMTSV
QSSLDADPDE VDLSGLVESI VDSDEEEDLA ESMDSLTVRD PVRECLEKDP VERTEDDIET
LLEFTQQLKA FTNMTLAVRR ALCAVMVFAV VERAGMVVLN DGEELDSWSV LINGAVEVEQ
SNGEIQQLCL GDCFGILPTM DRLLHCGVMR TKCDDCQFVC VTQADYFRIQ HQGEENTRRH
EENGRVILVT ELRGALDGAA RRGHVVIRGT PERLMLQLIE ENSITDPTYV EDFLLTHRTF
IDNPLLVASQ LLEWFDQAQV RDRVARVVLL WVNNHFTDFE TDPSMMEFLE AFETGLEREK
MQGQQRLLNI ACAAKARTRN VTLARPNRDE VLNFSILGGF ERGFGIFISK VDKQSKAEDV
GLKRGDQILE VNGQSFEHVN HAKALDILRA STHLSITVKS NLLAFKEMLQ IPDNSPRSRG
RASKPEIPRL QSDPRARLST HVDPMTPVNP LNPLIGGVPL LIPDNNVSPC KDAKKEHKGF
MTLGPKRRLQ KALMKMNILP KNTINDGVHV DDPLAPPHTP PGTGLAQTTT NLYHSKSNPD
LTSLYCYDDL RANDYPEHVL KVYKADQTCK YLLIHKETTA HEVVMLALQE FGITESSSNF
SLAEVSVGEG GMIKQRRLPD QLQNLAERIG LSSRYYLKTN GISETLVADE QAPELIRESQ
VHFLQLNAVE VAIQLTLQDF SIFRQIESTE YVDDLFVLKS RYGVPMLSQF AELVNREMFW
VVTEVCSEHN LVRRSKIIKQ FIKIARQCKE CKNFNSMFAI VSGLGHGAVS RLRASWEKLP
TKYQRLFSDL QELMDPSRNM SKYRQLVASE QTQPPIIPFY PVVKKDLTFI NLGNDSRVEG
LVNFEKLRMI AKEVRTLTNM CSSPYDLLTM LERGGQPPSS AMVALNQMTT GNQGGQTATV
KRRKKSTAAP NPKKMFEEAQ MVRRVKAYLA NMKVITDEER LHQLSVDCEP HAGAVTVAAA
VPLGGSRGRR HPSPTLSTTS SASSTSEGRK SIQGTKFGAA SPQAVRKMLA LSDPHKTRPY
QPKHCPPPLP VPGLALHSSG LEPSPGAPRR VGSGSRVPMH ERSHSDTPAS LPPPVDLSAE
SSSVTSLSNL QPLRKTLTSG SVTSSDSGHS TQLDSHSGSS VEAGGSPPPP QRRHSAMQGS
VIRGGAPPFP HAVAVLPPLP ADQNHNHNHH HHHHHHHHNQ QHYHDHHHHH HHHQPPTPQG
SMGLGGVSMG LGMPAPLPPG AGTTTIMTTT MSAMAAGNIP SITTMRPGMS SGPQCRQPPA
YKVAQQMARL HRLGRANSHE GVTYRTDHED GTTCNQIATV YTAHTPPPPP PPHPHTLPHF
GSSRLLRSRR
//
