ID E2B9T9_HARSA Unreviewed; 1032 AA.
AC E2B9T9;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Protein smoothened {ECO:0000256|ARBA:ARBA00035037};
GN ORFNames=EAI_16975 {ECO:0000313|EMBL:EFN87526.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN87526.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN87526.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL446605; EFN87526.1; -; Genomic_DNA.
DR AlphaFoldDB; E2B9T9; -.
DR STRING; 610380.E2B9T9; -.
DR EnsemblMetazoa; XM_011156983.3; XP_011155285.1; LOC105192693.
DR InParanoid; E2B9T9; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0009888; P:tissue development; IEA:UniProt.
DR CDD; cd15030; 7tmF_SMO_homolog; 1.
DR CDD; cd07451; CRD_SMO; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR035683; SMO_7TM.
DR InterPro; IPR041771; SMO_CRD.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..258
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 293..553
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 80..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..875
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1032 AA; 116817 MW; 172EBE17F49B0C99 CRC64;
MREASFGQDA DLVSWLAEIA CDSKDDINSW THESTRLIVY ITLHVVSLFW SSYHHNVRNM
IPLLVLCCLL PHRTSSELEP RFTTNNEAEN NTGKDMDLGS RHRIKDSSYL LDRYPIDMSS
DDMNCRRPAK CISLHKTTCM GMKLPYTHTT LDLIPEHVTQ NIVEERLYLL QALRHVPKCW
AVVQPFLCSI FMPKCVNNTV ELPSHEMCKL VLGPCRLLLN HTIWPSFAKC DDTELFRRSC
KNDIRELKFN ISGKCLKPLV PTDNALSIFD GVEGCGTQCY DPLFTPDEHK QIHSFIAWAA
GICCAFNLFT IITFLIDWRS ANKYPALVIF YINCCFMVSC IGWLAQFTFG RDVIVCRKDG
TLRMSEPSGE TLYCIITFIL VYYSLIAAVV WFVILTYAWH MSFQALGKIK DRIDKKGAYF
HLIAWCLPTV LTVTIMTLGE IDGNSVTGIC FVGYANHIAR ASFVLGPVLI GLLIGGYFLS
RGLFTLISLK ISSREVMSER ASAKIRETII RMGLFFIFTL AAVGVTFYCH IYEFLHSWQW
RQSFRNYMIC AITTKYLDES ECKMSIRPSA GKMQLHLLAP FFAGILMSSW VWTSSTVDTW
SRFLKRTFNC ETEEPIRLKK HKVIAQVFAK RKTFNNAGRL SISFHNTHED PVGLNFELNS
VASQDFSSTW AAALPKLVTR RGALVGSTTG SVSSNRRNSV DSEISYSFKC VSMESRRDSL
DSQISVQIAQ VKTTRKVAGR PNGRRGKNRR DFGKSGKSRS DKKVDPHSRR DSTTSQDSQL
VTTGAGHVPI QMPNMGRRLG NAGLDDRALI VEDYRGSKII DTKNAGMLLP FLFPRSCSDE
NLSSDEKRLD DPVVVDIEAE NAEKDEQDSD GEDSQPDEEV KMLSPEDTHE RGKAKSSNKN
CKTYSHESDR RNRESHRNKY VLKDETILKH LLQESSDIKI KNDSEKKETY RKVAAGDLAS
SLTSCCPELT RLMQDGQTGN AREMATQTSL PLDILEMEEL KQSIDEIINS RHCSSKGTQI
SPQLKKSKNI VT
//