ID E2BEU4_HARSA Unreviewed; 1253 AA.
AC E2BEU4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=EAI_04653 {ECO:0000313|EMBL:EFN85810.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN85810.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85810.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; GL447857; EFN85810.1; -; Genomic_DNA.
DR AlphaFoldDB; E2BEU4; -.
DR EnsemblMetazoa; XM_011139161.2; XP_011137463.2; LOC105182028.
DR EnsemblMetazoa; XM_019840841.2; XP_019696400.1; LOC109503734.
DR InParanoid; E2BEU4; -.
DR OMA; IQKHYSY; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF504; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EFN85810.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..464
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 546..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..607
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 685..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1253 AA; 140865 MW; 1AF1A7F37C8A306C CRC64;
MVTRMQLERS EVAFFIYTNG NTLRSNLTQR FSITDQDLHN MSTWPLVSVP RDESKTQTYD
VVSKEAFQAR LEDFRQKISS EESSISEVMA WYTSVNAAML DHLTNQIKET DNSGVWRYLI
AFKNLLRSIE SLGIASVEGI NYFGRGILLG DNYISYVRHE ALGRDLLNAA LTYVPSLKKF
YEELTRTMPE YDKIKARRDE ILRNQKREPS VDDAIAYFDS MATYIDELRK LQRELRHMIR
NYVNSTLQDA SNKEVAGIAI VVLVLMVSPI IIILMRNAVA TIQMYAANLA QKARELKREK
RKSDTLLFQM LPPSVAQQLK QTQQVPAEYY EAVTVYFSDI VGFTEIAAEN TPLEIVTFLN
SIYKLFDARI ECYDVYKVET IGDSYMVASG LPVRNGDKHV SEIATMALDL LAASSVFQVP
KRPGERLQIR SGAHTGPVVA GIVGSKMPRY CLFGDTVNTA SRMESTGEAL RIHISLEMKK
ALDAVGGFRI EHRGMVDVKG KGLMDTYWLE CKDGGIARAA ELDLPTFFED VRPVFMRRLR
EEGRKNRLSH PNLHITSVKA PPQSQSSIES QDSGTYEGTR STTPCPPSYS PASQRSRYSQ
PNLPTLLISY DRRSAGSPDR RIRMSQPTLN SSLSGINFFG MNRVGGGRLS YTSLRATSGD
NSINEEERLS TPNVHALGGS GSPRGSLTME RSSSRLSQPD VRRFNLRQDK RERLSQPTLV
TGDYYPGRGQ QRLSQPCLSS GREGVIGVHS PSPPPYPLKH KRFVPGALQT CQRDRLSQLD
IGSKYRNIMK DLGGGRDNSQ VKFNRDRFSI PELETQNDLR LIAGTPKQRF SLDSQLAKQR
FSLDSQDSCK SRLLPIASSP IFEHQQMKTE EMTGMTSGRL KSPTCEGLES VLVASTSPLF
PPSERRLLGP DFPFPRKSSK SPSPTKTSDV KTIGKPPPIP IRERMSVPEI RNSSLRRLLD
PPTRQRHSIA GNLRQTLLTP IKLQDFGGTG GRKSPRYSID DALEKLKRIE KEENRRNQEM
NEEKVQVKEQ DQQQQQQQQQ QEPKHIQKHY SYTYETGEDG SVSSSLGKLS VGGAPKRKYL
ESNFDENEQV ITTVIETDVP MIMSSPRLKF AKKMQAYSSE TPKWIRKYLE GESPNIGRKT
STGGGGSGKE TGRINRRSSR RKSSLESIES VTKKPEEKPR SKSVSCEERN TNGITVAVAE
QKSVMNTYVR IVPSSNAQEN RYEVGVESAV SDWKTDSRGP YGDDTDTDDS TSI
//