ID E2BF31_HARSA Unreviewed; 281 AA.
AC E2BF31;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 28-JUN-2023, entry version 55.
DE RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN ORFNames=EAI_10522 {ECO:0000313|EMBL:EFN85709.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN85709.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85709.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC clearance by RNA polymerase. {ECO:0000256|ARBA:ARBA00025581,
CC ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC {ECO:0000256|PIRNR:PIRNR016398}.
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DR EMBL; GL447910; EFN85709.1; -; Genomic_DNA.
DR RefSeq; XP_011137573.1; XM_011139271.2.
DR AlphaFoldDB; E2BF31; -.
DR STRING; 610380.E2BF31; -.
DR EnsemblMetazoa; XM_011139271.3; XP_011137573.1; LOC105182096.
DR GeneID; 105182096; -.
DR KEGG; hst:105182096; -.
DR InParanoid; E2BF31; -.
DR OMA; HMKARHQ; -.
DR OrthoDB; 3061109at2759; -.
DR PhylomeDB; E2BF31; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005673; C:transcription factor TFIIE complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR040501; TFA2_Winged_2.
DR InterPro; IPR016656; TFIIE-bsu.
DR InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12716:SF8; TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA; 1.
DR PANTHER; PTHR12716; TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT; 1.
DR Pfam; PF18121; TFA2_Winged_2; 1.
DR Pfam; PF02186; TFIIE_beta; 1.
DR PIRSF; PIRSF016398; TFIIE-beta; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51351; TFIIE_BETA_C; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016398};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016398};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR016398};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR016398}.
FT DOMAIN 59..140
FT /note="TFIIE beta"
FT /evidence="ECO:0000259|PROSITE:PS51351"
FT REGION 20..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 32722 MW; 1CD4D4EFEF46F410 CRC64;
MDPALLRERE LFKKRALTTP TVEKKKKEQE ILRDDSSKKK PKPSSISTGP KLDMVNYKTM
AGSTQYKFGV LAKIVKHMKA RHQDGDDHPL TLEEILDETN QLDVGLKVKQ WLQTEALVKN
PKIDVTTDSR FVFKAMYKIK DKKSLLRLLK QHDLKGLGGI LLEDIQESLP HCEKHLKALQ
NEILFITRPL DKKKIVFYND KTAQFPIDEE FQKLWRAVAV DAMDDQKIDE YLEKQGIRSM
QDHGLKKPAP LKRKKPVNRR KQFKKPRDNE HLADVLETYD N
//
