ID E2BI71_HARSA Unreviewed; 3441 AA.
AC E2BI71;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 {ECO:0000313|EMBL:EFN84602.1};
GN ORFNames=EAI_12752 {ECO:0000313|EMBL:EFN84602.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN84602.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN84602.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL448457; EFN84602.1; -; Genomic_DNA.
DR STRING; 610380.E2BI71; -.
DR InParanoid; E2BI71; -.
DR OMA; GVCHLIE; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF4; BLUE CHEESE; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2401..2525
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2553..2846
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2991..3025
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3372..3432
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1832..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2371..2392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3126..3153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3167..3272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3169..3185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3186..3204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3205..3226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3245..3272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3441 AA; 384667 MW; B34DE36C730D2698 CRC64;
MRKLRGGTSV GGMGSSGTGG LDDCAGGANP QHTALGLMHL KKLFSEYTHP SHPLSDAERD
DKLYNMLPLF CKVFGSSPSG DMNEKFWDIL AFTQQVSRLM VSEIRRRASN QSTETASCAI
VKFLEIENSE ESSNGWMLLS ALNLLAAGDT SLIQAMTAAS VPSTLVKCLY LFFDLPEMNE
EDADITDANS EFTPRERRIL LQKIFVQLLV RLCSHPYPAE ELARKDDLTL LFSAITSWCP
QYNVMWRKSA AEVLMTLSRH GLTQNVVAYI HNKGCIALCI DNMQRVPELA PLEVVEMFVT
VFCFLKDSSE VSQTLLDDFR ACQGYIFLSE FLLKHAPSRL EQDNRAEAQD AIRNLVLMLA
SLTMCGHTEL KPSQASMGSL FQMLGFSLPQ PSNRGGSVRN IQAFQVLQSV FVKSNSPLLC
CTILDAISSV YHSDNANYFI LEGQNTLSQF AEKIHLKNPE IQEKFFQLLE FIVFQLNFVP
CKELISLSIL LKTNNSVSCS IMCMETLLNI LRHNTIFKDV YREVGMLEVF VTCLHRYATL
LKDKQAAVDQ GLEYIICPED ERLGALVMEA LTTLLASNVQ NANVFRECGG ARCAHNLVPY
VDCRYQALGI VRELILSAGG DDDMATLLGV MHSAPPNALI LKTHILKSLL ACLRESHRTR
TVFRKVGGFV YVMSVLVSLE GQLGAQRSEN AEPCNDIVQR TMQDESQLLI LLYVVFHTIS
TAMRFEPANA KFFHHEICQS SLCDTLRLLG CFSTQTKLIE MDMIPTMNYH NMLVSLFTGS
VLEPVFPDDM PKTLGYACLL LRLLYDVALD SFDKPNLVNV GIRSPSHKQN NVEQQKSFDS
PGSGKRCIIN SLNLSPPAPE PIVIHPGIVV GMLHLLPSIS EPSNPQMALA LQLYVAEIIK
SLVRSERNQQ VMCEAGMAGD LLSVGRTALQ DETHPLHQPL QYIIERLAAQ SLEPRDLREF
LRLGDPLCCI SLDDIEPNKP RGGPVPLTRI KTLVSMTTPK DFRAHGSCTL PPFVELDMSA
EGFACLYLPS VAPQSTTPPT VVAADNSVLG GIGSGDRLFP PQTGLTYSTW ICVDKFSDPR
TDPHCVRLLT LVRTPQSAQP AKDLICLTAV LSARDKAIIV STQETLISQN SGEWEPEGTG
ECGARVWCPD LLHEGQWHHI AIVLNRAVLK NSSFSLYLDG QHIHSQKVTI IKLRLHYISQ
VAGGGAANLT VASPVYGYIG TPPCWRRYSR LTWKQGPCHL VEEVFNSQNI ATLFKLGPHY
MGSLQAPQLS GPEPLMALVG EEKVVFGLNA KAMSQLTLAK IRKVYSRADN KSIAKQLGMS
SHENATPIRV LHNSAGHLSG PARALGGVVV GYLGVRVFSP KPVATMIDNV GGCSVLLGLI
AMAQDVESLY AAVKALVCVV RSNQAAQQEM DRRRGYQTLA MLLRRKCPLL NSHILHLTFS
LVGTVDSGRE TSAIPNVTAF QDLLCDLQVW HEAPGELLRS LLEHLYELIA ESSEKRTNLR
LMRDLQLVHK LLHILGEVKL GSTRQILLAL LSILLSQPRQ ADLLWFGQFI VATLPLCPEK
HLILREGEGI KDGEGENILL RNRCLQLLHS LLFNGSKVNA KMCEEVATVL GLDWVLLFLQ
SGLHSTTVVW GLRILVAVCS VQSILQKFKE GTSNGGWLRH TDHNKMALAL GCHQQMSTGE
IKPSGLHVPG FQHLGWLLPQ HIDLVPELYF LFIALMMGQP VKLLPTDSKL DLDNVWNFMF
GVPANHTLSS FASRINLCPE AVVTLLAMVR TMLNSHSNNP EMLPAWLNDY PVTIIQFLFF
LYHNFTDFMQ VFMSAEVLGA LAGTLFPKPA SSSQDSSGAS TPADEQEPVL VRSPSKDVGL
TNHPAKKFVM DFLRVIVVDS LSLPVTAKSP PAIDLVLEAW PEHASTGQQM RYQTEVLSIL
MEHLLAADVL IGEQAALPVV PGGSVNNITN NVCYVAARIV DKLWQGALTK DPHEVFDFIV
KLIGQAKRRP GAVSMEGLHH CLNRTILFLL SRATDSIADQ MAVLEALHKL TTHRLLVFGA
GNHELEFIGC LTYCLLQLTA DIKIMLDTNM KTTWHVNPQV ESSDDRLTSH QGHNLMAVAA
TRVWEELYVC KKPAIEEVFK VTLSTPVGNE RAPELSLVRE QVHEAASKLW LNYVVLERRA
SYRVPWELHN QIQSKIQKVT GGLTRLASRT KVRKEESVRV RLRLHQNTVA QWTEQHVALV
RELAAVRRLQ HQQTNLHTQR YVYQEWLQTE TELTRERGLW GSPTSTKLDK WMLDMTEGPC
RMRKKMMKNE LFYIHYPYRP ELEHPDNKQL KYKVATSMDS KEYYLKQLGN SSGMFERERD
PVIDDTPLNV NEASTESEPP IVPCTLERHA SEPDEAPEDN EQEEENNQTV PDNQTLLRLL
EEHEKISHMF RCARIQGLDT TEGILLFGKE HFYVIDGFTL LKTREIRDIE SLPEAYEPIL
PSPGSPRRSR AMRQCSKFNY EDIREVHKRR YLLQPMALEV FSGDGRNYLL AFPRKVRNKV
YQRFMNVATA IADSAQQSVA GQKRTANVEQ ATGLLSNLIG ETSVTQRWVR GEISNFQYLM
HLNTLAGRSY NDLMQYPIFP WILADYDTEE LDFMDPSTFR DFSKPMGAQS PERLLQFKKR
YKEWDDPHGE TPPYHYGTHY SSAMIVCSYL VRMEPFTQHF LRLQGGHFDL ADRMFNSVKE
AWLSASKHNM ADVKELIPEF FYLPEFLVNS NHFDLGSKQS GVQLGDIVLP PWAKQDPREF
IRVHRLALEC DYVSQHLHQW IDLIFGCKQN GPAAVEAVNV FHHLFYEGNV DIYNIDDPLK
KNATIGFINN FGQIPKQLFK KPHPAKKMSQ RTSVIDPGPI TPGLSITTSD KLFFHNLDNL
KPSLQPIKEL KGPVGQILHV DKAVLAVEQN KTLIPPSYNK YVAWGFADHS LRIGNYDSDK
AIFVGEAMMQ SSGEIVACVC PSSKLIVTAG TSSVVTVWEY AKRQLSIKQC LYGHTDAVTC
LSSSPAYNVI VSGSRDGTAI IWDLSRCLFV RQLRGHAGPV AAVAINELTG DIATCAATWL
HVWSINGEEL ASVNTCVGRA DRMQQILCVA FSQTHEWDSQ NVIMTGSTDG VARMWSMDYV
QVPAEEEKPE EMVVAKEKNE GQNNEENQTE TTKKRVHELV KQMSISAEGS GILMKSGSES
SLSEAENAKE ASRLHEEKEE CSDNESSNGS NNKPSPQSNH ASTVVLRRKS RGNPMFRKSE
GGGRADSEGT QTSESASNPG DSEGALRASK SDTSLTDSFV MVTEADTKPR KINPQNILRD
GFKWQRQLVF RSKLTMHTAY DRKDNAEPAS ITALAVSRDH RTVYVGDTRG RVFSWSVCQQ
PGRMVADHWV RDEGADWCAG CNVRFNLYER KHHCRNCGEV FCSRCSRFES KISRLGILKP
VRVCQGCYSS LRSQHSAESN T
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