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Database: UniProt
Entry: E2BJ10_HARSA
LinkDB: E2BJ10_HARSA
Original site: E2BJ10_HARSA 
ID   E2BJ10_HARSA            Unreviewed;      1104 AA.
AC   E2BJ10;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=EAI_13848 {ECO:0000313|EMBL:EFN84355.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
OC   Vespoidea; Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN84355.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN84355.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; GL448543; EFN84355.1; -; Genomic_DNA.
DR   InParanoid; E2BJ10; -.
DR   OMA; HNITDEI; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008237};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    117    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    155    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    188    207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    360    382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    490    511       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    523    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    616    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    676    704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    890    907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    927    948       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    960    986       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    393       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      489    731       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      888   1041       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      810    837       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1104 AA;  122874 MW;  E212C561A467B25D CRC64;
     MSAGGDGGSA LGPPGLPGVQ PTAATPFNAT PPVVGQQQYG VGGDAQLGNA QPPPQSQTGV
     GPGAATAAAA ASKSAPKRPA RRGGKPPPDR PTRALFCLPL KNPLRKMCIS VVEWKPFEWL
     ILMTIFANCV ALAVYTPYPF GDSNQTNQYL EKIEYVFLVI FTVECVMKII AYGFVAHPGA
     YLRNGWNLLD FTIVVIGMVS TVLTILMKEG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS
     ILRAMIPLLH IALLVLFVII IYAIIGLELF SGKMHKTCRH NVTGEIMDNP VPCGPGGFQC
     SRVGAEYYCS KQFWEGPNYG ITNFDNFGLA MLTVFQCVTL EGWTDVLYNI EDAMGSSWQW
     IYFISMVILG AFFVMNLILG VLSGEFSKER EKAKARGDFH KLREKQQIED DLRGYLDWIT
     QAEDIEPEAD EPKMQDGKSK QQNEMESTDQ LEGDEEGVQQ ESIWKKKKRD LDRVNRRMRR
     ACRKAVKSQV FYWLIIILVF LNTGVLATEH YNQPRWLDDF QEITNMFFIV LFSMEMMLKM
     YSLGFQGYFV SLFNRFDCFV VIGSISEMIF TNTHVMPPLG VSVLRCVRLL RVFKVTKYWR
     SLSNLVASLL NSIQSIASLL LLLFLFIVIF ALLGMQVFGG KFSFSDMEEK TRHNFDSFWQ
     SLLTVFQILT GEDWNVVMYV GILAYGGVAS IGVLACVYFI ILFICGNYSN ADILLNVFLA
     IAVDNLADAE SLTAIEKEAE EEAEKNKSRS GSPTRDEVSG EAGDDGGEGT GGEDEGAGTD
     LEHDPNETME DYEAALDTET SEKSEDMNTH TKVRLNIESD EEEVEEEEEE GVEQEEMQED
     GQEVSARPRR MSEYNMATKK EPIPAGSAFF IFSSTNRFRV FCHWFCNHSY FSNVILICIM
     ISSAMLAAED PLKASSYRNQ ILNYFDYFFT TVFTIEICLK MISYGFIIHD GAFCRSAFNL
     LDLLVVCASL VSMTFTSGAF SVVKVLRVLR VLRPLRAINR AKGLKHVVQC VIVAVKTIGN
     IVLVTSLLQF VFAVIGVQLF KVGLSGPDAT RPRDYLSLCL SLSLSLSLSH SLSLSLSLSL
     SLSLSLSLSL SLSLSHSLVP SNLL
//
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