ID E2BXW1_HARSA Unreviewed; 833 AA.
AC E2BXW1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=EAI_03176 {ECO:0000313|EMBL:EFN79468.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN79468.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN79468.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; GL451328; EFN79468.1; -; Genomic_DNA.
DR RefSeq; XP_011147087.1; XM_011148785.2.
DR AlphaFoldDB; E2BXW1; -.
DR STRING; 610380.E2BXW1; -.
DR EnsemblMetazoa; XM_025305606.1; XP_025161391.1; LOC105187784.
DR InParanoid; E2BXW1; -.
DR OMA; ACCERFD; -.
DR OrthoDB; 2898719at2759; -.
DR PhylomeDB; E2BXW1; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 424..552
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 650..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 367..394
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 833 AA; 94951 MW; 941510AA9B99F684 CRC64;
MYGLILENLA EYIRQVYGED RWEEIRRQAS VNQPSFSVHQ VYPENLIPRL AKKAIQVLGV
TEKEFFDQMG VHFVGFVGQY GYDRVLSVLG RHVRDFLNGL DNLHEYLKFS YPRMRAPSFI
CENETRQGLT LHYRSKRRGF VYYTMGQIRE VARHFYHKEL QIELVREEVL FDTVHVTFQL
TFDNRAFTLA SLAMTREEKH LPIGACVLFE IFPFCIVFGS DMVVRSIGNS LMVILPDLVG
KKITYFFDLV RPLIAFKFQS ILNRTNNIFE LVTVEPVLTD RLNDRHRNEI LLSDELETVE
DKTLRLKGQM IYMDNWKMMM YLGTPVMPDL NALIATGLYI NDLSMHDFSR DLMLAGTQQS
VELKLALDQE QLKSKKLEES MRKLDDEMKR TDELLYQMIP KQVADRLRNG ESPIDTCEMF
DSVSILFSDV VTFTEICSRI SPMEVVSMLN AMYSLFDTLT ERNRVYKVET IGDAYMVVSG
APVKENDHAD RVCDMALDMV EAITDLKDRS TGNHLQIRVG IHSGAVVAGI VGLKMPRYCL
FGDSVNTASR MEATSQAMQI HISQSTQELL SPTYKVKERG EIEVKGKGTM KTYWLEKRER
RSVTTKGITI QEPHQWHTKN FEKRVSSVSA IGLISPGMFE KPISGDILSR RSSKISSPTP
PGPSGIFPEE RRIYSPITFQ DVARRSVANS PTKNVEVKEC RSNSMGAVGV RNASDMFISL
LSDTEEHFRQ HRNSLSARSD NQSVAVHIKP EVRINATSSS SSSTFSERSD DETNPSLDLQ
VQKENVSNTN ECAAFNSNLS NSQLLMQQDQ CCPGFTMSKG SKMRYQGNGC IIF
//
