ID E2C109_HARSA Unreviewed; 936 AA.
AC E2C109;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Discoidin domain-containing receptor 2 {ECO:0000313|EMBL:EFN78330.1};
DE Flags: Fragment;
GN ORFNames=EAI_07512 {ECO:0000313|EMBL:EFN78330.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN78330.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN78330.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; GL451853; EFN78330.1; -; Genomic_DNA.
DR AlphaFoldDB; E2C109; -.
DR InParanoid; E2C109; -.
DR OMA; REKPFQH; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.60.120.1190; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR048525; DDR1-2_DS-like.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF622; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF21114; DDR1-2_DS-like; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00231; FA58C; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EFN78330.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 413..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..124
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 642..927
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 366..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFN78330.1"
FT NON_TER 936
FT /evidence="ECO:0000313|EMBL:EFN78330.1"
SQ SEQUENCE 936 AA; 105542 MW; 2495BB6B01118F97 CRC64;
RLRKETAGGA WCPKSQIEKG VREWLQVDLP GAHVVTGVQT QGRYDHGRGQ EYVEDYTLEY
RRPGFTEWRR YKRWDNKEVL AGNSDTSTVV SHKLIPPIFA SQIRILPHSE HRRTVCLRIE
LKGCRDMISL RVTPRSVAFF CPSLPPAPPL TLLAPCTFSL SRYLDRDAAR SSTQSIGGLV
SYTIPDTSMP ELSDVSYDGE RQDNLLTDGL GCLIDGEVGA DNYRQDMGDG KGTGWVAWLR
DTFVENFVEL IFEFEATLVF EAVHIYTNNY FSRDVQVFSK ADIWFSTDGE TYEDEPLLYS
YIPDLVLENA RNVSIGLHGR RGCLLKLHLY FAARWIIISE VMFDAKSSRC RDFPAGLVPA
LDRRKLRPSS ASSSSSSSAT TTTTTTSRSR WSREHSPLDE LIYFHYGQEY LEVLIGVLTA
IILLLLLVFF IILFLNRRQK LQSSPTGLLL NLTPGGMLTA ETANHVSPDI PEDVSMHESL
TMEQFNSPLV SPQYKSTYAI VASSEHTYAG AMLLRVGPRD SQPRGRQDSE VAIVFPESPK
DFQNIEIPEE SVRLDARPES AVGPSSCSSS PTNSPARHSQ HYRTLQSYSS PTRKLNIAVT
PNHQRDVDQI PAPVVSWNIA PSMNKPYKCK EIEPTNIPRQ CLRTTEKLGS RNVGEVIICE
AVGLDEVVSG APRLVVARVP LCSGDIRTNN AVDQMREVRF LSCLSDPNVA RVLGVCTVEP
VPWTIIEYTE LGDLAHYLQY SVPLTGTLRP NCNLKALSQS CLLYMGTQIA SGMRFLESKN
LVHKDLAARN CLVGRCYTVK VTDIAMCSDL YKKDYSDISD IGGRPPAPIR WLPWESILLD
RYTCSSSIWS FAVTLWEVMS LAREKPFQHL SNDQVIQNAE HMYYGAELQV FLPKPTMCPE
EVYRMMCSCW RRDETSRPTF KDIYTFLKNI ITDYRP
//
