ID E2D9D5_CAPSP Unreviewed; 293 AA.
AC E2D9D5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN Name=blaSPU-1 {ECO:0000313|EMBL:ADK47391.1};
OS Capnocytophaga sputigena.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1019 {ECO:0000313|EMBL:ADK47391.1};
RN [1] {ECO:0000313|EMBL:ADK47391.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=507 {ECO:0000313|EMBL:ADK47391.1};
RA Ehrmann E., Handal T., Giraud-Morin C., Bonnaure-Mallet M., Fosse T.;
RT "Prevalence of beta-lactamase genes in Capnocytophaga spp., and
RT characterization of Spu-1, a new ESBL in Capnocytophaga sputigena.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; GQ919044; ADK47391.1; -; Genomic_DNA.
DR RefSeq; WP_063864748.1; NG_050141.1.
DR AlphaFoldDB; E2D9D5; -.
DR SMR; E2D9D5; -.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 39..264
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 293 AA; 33024 MW; 8E8D156E3932D4DA CRC64;
MKKYFSFCLL GIFIFCFSQQ NLKRDITKII QGKNALVAVS VMNSKGKTEV NINGNKKVPM
LSVFKFHIAL AVLDLVDRGI LDLEQNIFVK KSELLENTWS PIRDKYPNGN VNIPLREIIE
HTVSQSDNNG CDILLRLIGG VDTVQKFIES KGIKDFAIKY NEEEMNKNGK SIYSNYTTAN
ASSRLLQKFY NGEIISESSR DFLFRIMYET STGADRLISL LPPDVIVAHK TGTSGIVSGI
QAATNDVGII ILPDDEYYTI SVFVINSKEN TSTNEKIIAD ISKTVWDYYF QNK
//
