ID   E2DNV1_CVH22            Unreviewed;       153 AA.
AC   E2DNV1;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   28-JUN-2023, entry version 27.
DE   RecName: Full=Replicase polyprotein 1ab {ECO:0000256|ARBA:ARBA00022087};
DE   AltName: Full=ORF1ab polyprotein {ECO:0000256|ARBA:ARBA00029611};
DE   Flags: Fragment;
OS   Human coronavirus 229E (HCoV-229E).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Duvinacovirus.
OX   NCBI_TaxID=11137 {ECO:0000313|EMBL:ADK37685.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ADK37685.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HCoV/229E/N02 {ECO:0000313|EMBL:ADK37685.1};
RA   Wang W.;
RT   "Highly sensitive monitoring system of causative viruses in acute
RT   respiratory infection in children and emergence of new variants and of
RT   epidemics in Shanghai.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family.
CC       {ECO:0000256|ARBA:ARBA00008087}.
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DR   EMBL; GU068551; ADK37685.1; -; Genomic_RNA.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR046441; RdRp_CoV.
DR   InterPro; IPR001205; RNA-dir_pol_C.
DR   Pfam; PF00680; RdRP_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS51948; COV_NSP12_RDRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..153
FT                   /note="Nsp12 RNA-dependent RNA polymerase"
FT                   /evidence="ECO:0000259|PROSITE:PS51948"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADK37685.1"
FT   NON_TER         153
FT                   /evidence="ECO:0000313|EMBL:ADK37685.1"
SQ   SEQUENCE   153 AA;  16932 MW;  04FA993F7244B5B3 CRC64;
     TKRNVLPTMT QLNLKYAISG KERARTVGGV SLLATMTTRQ FHQKCLKSIV ATRNATVVIG
     TTKFYGGWDN MLKNLMADVD DPKLMGWDYP KCDRAMPSMI RMLSAMILGS KHVTCCTASD
     KFYRLSNELA QVLTEVVYSN GGFYFKPGGT TSG
//