ID E2FU13_9THEO Unreviewed; 409 AA.
AC E2FU13;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=CTP synthase (glutamine hydrolyzing) {ECO:0000256|ARBA:ARBA00012291};
DE EC=6.3.4.2 {ECO:0000256|ARBA:ARBA00012291};
DE Flags: Fragment;
GN Name=pyrG {ECO:0000313|EMBL:ADN19453.1};
OS Thermoanaerobacter uzonensis.
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacter.
OX NCBI_TaxID=447593 {ECO:0000313|EMBL:ADN19453.1};
RN [1] {ECO:0000313|EMBL:ADN19453.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JW/IW_A615_31 {ECO:0000313|EMBL:ADN19453.1};
RA Wagner I.D., Varghese L., Wiegel J.;
RT "Universally conserved protein coding gene sequence heterogeneity among
RT Thermoanaerobacter uzonensis isolates from geothermal springs of Kamchatka,
RT Russian Far East.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-
CC glutamate + phosphate; Xref=Rhea:RHEA:26426, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:43474, ChEBI:CHEBI:46398,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000314};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway;
CC CTP from UDP: step 2/2. {ECO:0000256|ARBA:ARBA00005171}.
CC -!- SIMILARITY: Belongs to the CTP synthase family.
CC {ECO:0000256|ARBA:ARBA00007533}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00605}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HM191136; ADN19453.1; -; Genomic_DNA.
DR AlphaFoldDB; E2FU13; -.
DR UniPathway; UPA00159; UER00277.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003883; F:CTP synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01746; GATase1_CTP_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR004468; CTP_synthase.
DR InterPro; IPR017456; CTP_synthase_N.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR033828; GATase1_CTP_Synthase.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00337; PyrG; 1.
DR PANTHER; PTHR11550; CTP SYNTHASE; 1.
DR PANTHER; PTHR11550:SF0; CTP SYNTHASE-RELATED; 1.
DR Pfam; PF06418; CTP_synth_N; 1.
DR Pfam; PF00117; GATase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 1..185
FT /note="CTP synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06418"
FT DOMAIN 220..404
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADN19453.1"
FT NON_TER 409
FT /evidence="ECO:0000313|EMBL:ADN19453.1"
SQ SEQUENCE 409 AA; 46314 MW; 91E42FE78BC8DB0E CRC64;
LTKNSNVTAG KVYWTVITKE RKGDYLGATV QVIPHITNEI KERVYRVAKE KNVDVVITEI
GGTVGDIESL PFLEAIRQVA IEQGRENVMF IHVTLVPHLG KTGELKTKPT QHSVKELRSI
GIQPDMIVCR TELPLTQDLK EKIALFCNVS VEAVIENRDV ESIYQVPLEL ERQKVDEYVL
KRLNLPIEES DLKEWREYVE REKNPTRQVE VALVGKYVDL HDAYISVVEA LKHGGVYHRA
AVNIRWVNAE HVNDETVEKL LKGADGILVP GGFGDRGIEG KIRAIQYARE NKIPYLGLCL
GMQCAVIEFA RNVAGLKGAN STEFDPDTSH PVIDLMPEQK DIDEKGGTMR LGVYPCKVIE
GTKAYEAYKD ELIYERHRHR YEFNNQYREL LTSKGLVLSG LSPDERLVE
//