ID E2I8L8_MOUSE Unreviewed; 69 AA.
AC E2I8L8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=MHC class II antigen alpha chain {ECO:0000313|EMBL:ADN26202.1};
DE Flags: Fragment;
GN Name=H2-Aa {ECO:0000313|EMBL:ADN26202.1};
OS Mus musculus musculus (eastern European house mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=39442 {ECO:0000313|EMBL:ADN26202.1};
RN [1] {ECO:0000313|EMBL:ADN26202.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20823902; DOI=10.1038/hdy.2010.112;
RA Cizkova D., de Bellocq J.G., Baird S.J., Pialek J., Bryja J.;
RT "Genetic structure and contrasting selection pattern at two major
RT histocompatibility complex genes in wild house mouse populations.";
RL Heredity 106:727-740(2011).
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DR EMBL; HM443591; ADN26202.1; -; Genomic_DNA.
DR AlphaFoldDB; E2I8L8; -.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:UniProt.
DR GO; GO:0005764; C:lysosome; IEA:UniProt.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:InterPro.
DR GO; GO:0042605; F:peptide antigen binding; IEA:UniProt.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:UniProt.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF59; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ ALPHA 1 CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}.
FT DOMAIN 1..69
FT /note="MHC class II alpha chain N-terminal"
FT /evidence="ECO:0000259|SMART:SM00920"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADN26202.1"
FT NON_TER 69
FT /evidence="ECO:0000313|EMBL:ADN26202.1"
SQ SEQUENCE 69 AA; 7832 MW; 40B292DC550ABEF3 CRC64;
GISVYQSPGD IGQYTHEFDG DERFYVDLDK KETVWMLPEF GQLASFDPQG GLQNIATVKH
NLEILTKRS
//
