ID E2IUC8_SHV1 Unreviewed; 517 AA.
AC E2IUC8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Virion host shutoff protein {ECO:0000256|ARBA:ARBA00018606};
GN Name=UL41 {ECO:0000313|EMBL:ADO13786.1};
OS Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset
OS herpesvirus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus saimiriinealpha1.
OX NCBI_TaxID=10353 {ECO:0000313|EMBL:ADO13786.1, ECO:0000313|Proteomes:UP000127069};
OH NCBI_TaxID=9481; Callithrix.
OH NCBI_TaxID=9520; Saimiri (squirrel monkeys).
RN [1] {ECO:0000313|EMBL:ADO13786.1, ECO:0000313|Proteomes:UP000127069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV 5-4 {ECO:0000313|EMBL:ADO13786.1};
RX PubMed=21130483; DOI=10.1016/j.virol.2010.11.008;
RA Tyler S., Severini A., Black D., Walker M., Eberle R.;
RT "Structure and sequence of the saimiriine herpesvirus 1 genome.";
RL Virology 410:181-191(2011).
CC -!- SUBUNIT: Interacts with human EIF4H, EIF4A1 and EIF4A2; interaction
CC with eIF4AI and EIF4A2 presumably allows Vhs protein to associate with
CC the eIF4F cap-binding complex. {ECO:0000256|ARBA:ARBA00011134}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the herpesviridae VHS protein family.
CC {ECO:0000256|ARBA:ARBA00009669}.
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DR EMBL; HM625781; ADO13786.1; -; Genomic_DNA.
DR RefSeq; YP_003933798.1; NC_014567.1.
DR GeneID; 9829315; -.
DR KEGG; vg:9829315; -.
DR OrthoDB; 6970at10239; -.
DR Proteomes; UP000127069; Genome.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039595; P:induction by virus of catabolism of host mRNA; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR Pfam; PF00867; XPG_I; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00023258};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023258};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW Reference proteome {ECO:0000313|Proteomes:UP000127069};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT DOMAIN 204..247
FT /note="XPG-I"
FT /evidence="ECO:0000259|Pfam:PF00867"
FT REGION 108..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57955 MW; 7B0AE5012B8DC42F CRC64;
MGLFGMMKFA YAHRLVHRQS IRPPAGMVVP VAVDLWNVMY TLVEKYAQRY PAYSDEAITV
RCLAHLLGVL AKRRLYPIFV TDRGADCNGR VVYGAKAILA RTTAQYGSGE AAGYDDTDAE
SPLPSPLDYT APGPDDRRSA YAPGTAFSSI RRRGRPAPRL SQSPGEPAPP LGGAPASTRR
PSGGRSSGRL AHQLCMRVVR ALGYPYVNSG QMEADDACAN LYHTNTVAYV FSTDTDLLLM
GCDIILDVGP CFLPTIRCRD VLRYLKMSYP QFLAMFVRCH TDLHPGHTCR SVDDVLQDFN
WFSPGSHPEP DPDSGSDSDW SLHISRRSRR RSKKKSIPDH VTESQISWAA ILEADAPGAV
PDPTEDDEFY EDFQHLCGGF DAQRLDDDAA ADADSEESLH ASHQRYTITR RRNIIRDATE
ALDWLPEPQT REDVVERRFV KYVISLITPR QQGSWTLLKR VPVFQDERDV DVVQYAVQRH
VAYPEDAEQV LAQLWYTVPA PSPYQSVLDR FWNDSLN
//
