GenomeNet

Database: UniProt
Entry: E2LB41_MONPE
LinkDB: E2LB41_MONPE
Original site: E2LB41_MONPE 
ID   E2LB41_MONPE            Unreviewed;       136 AA.
AC   E2LB41;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE            EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
GN   ORFNames=MPER_03335 {ECO:0000313|EMBL:EEB97360.1};
OS   Moniliophthora perniciosa (strain FA553 / isolate CP02) (Witches'-broom
OS   disease fungus) (Marasmius perniciosus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Marasmiineae; Marasmiaceae; Moniliophthora.
OX   NCBI_TaxID=554373 {ECO:0000313|EMBL:EEB97360.1, ECO:0000313|Proteomes:UP000000741};
RN   [1] {ECO:0000313|EMBL:EEB97360.1, ECO:0000313|Proteomes:UP000000741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FA553 / isolate CP02 {ECO:0000313|Proteomes:UP000000741};
RX   PubMed=19019209; DOI=10.1186/1471-2164-9-548;
RA   Mondego J.M., Carazzolle M.F., Costa G.G., Formighieri E.F., Parizzi L.P.,
RA   Rincones J., Cotomacci C., Carraro D.M., Cunha A.F., Carrer H., Vidal R.O.,
RA   Estrela R.C., Garcia O., Thomazella D.P., de Oliveira B.V., Pires A.B.,
RA   Rio M.C., Araujo M.R., de Moraes M.H., Castro L.A., Gramacho K.P.,
RA   Goncalves M.S., Neto J.P., Neto A.G., Barbosa L.V., Guiltinan M.J.,
RA   Bailey B.A., Meinhardt L.W., Cascardo J.C., Pereira G.A.;
RT   "A genome survey of Moniliophthora perniciosa gives new insights into
RT   Witches' broom disease of cacao.";
RL   BMC Genomics 9:548-548(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001633};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEB97360.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ABRE01006201; EEB97360.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2LB41; -.
DR   STRING; 554373.E2LB41; -.
DR   KEGG; mpr:MPER_03335; -.
DR   HOGENOM; CLU_1875953_0_0_1; -.
DR   InParanoid; E2LB41; -.
DR   OrthoDB; 294181at2759; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000000741; Unassembled WGS sequence.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000741};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          10..112
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF00218"
SQ   SEQUENCE   136 AA;  14483 MW;  C84471E3935336DF CRC64;
     MSTSKPPTIL EKIYAQRQKD VDIAKSTPGT SPEDLKTYLE MNLAPPQIPL VQRLKTNPST
     GSANSSLSLM AEIKRASPSK GEIAMNINPA QQALTYARSG ASVISVLTEP TWSTDLAGYA
     SVDNGYGSNR PVSEDG
//
DBGET integrated database retrieval system