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Database: UniProt
Entry: E2NBV5_9BACE
LinkDB: E2NBV5_9BACE
Original site: E2NBV5_9BACE 
ID   E2NBV5_9BACE            Unreviewed;       298 AA.
AC   E2NBV5;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Signal peptidase I {ECO:0000256|RuleBase:RU362042};
DE            EC=3.4.21.89 {ECO:0000256|RuleBase:RU362042};
GN   Name=lepB {ECO:0000313|EMBL:EEF90615.1};
GN   ORFNames=BACCELL_01762 {ECO:0000313|EMBL:EEF90615.1};
OS   Bacteroides cellulosilyticus DSM 14838.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=537012 {ECO:0000313|EMBL:EEF90615.1, ECO:0000313|Proteomes:UP000003711};
RN   [1] {ECO:0000313|EMBL:EEF90615.1, ECO:0000313|Proteomes:UP000003711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14838 {ECO:0000313|EMBL:EEF90615.1,
RC   ECO:0000313|Proteomes:UP000003711};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEF90615.1, ECO:0000313|Proteomes:UP000003711}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14838 {ECO:0000313|EMBL:EEF90615.1,
RC   ECO:0000313|Proteomes:UP000003711};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Bacteroides cellulosilyticus (DSM 14838).";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC         from secreted and periplasmic proteins.; EC=3.4.21.89;
CC         Evidence={ECO:0000256|RuleBase:RU362042};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; Single-
CC       pass type II membrane protein {ECO:0000256|RuleBase:RU362042}.
CC   -!- SIMILARITY: Belongs to the peptidase S26 family.
CC       {ECO:0000256|ARBA:ARBA00009370, ECO:0000256|RuleBase:RU362042}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEF90615.1}.
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DR   EMBL; ACCH01000141; EEF90615.1; -; Genomic_DNA.
DR   RefSeq; WP_007211137.1; NZ_JANSWE010000025.1.
DR   AlphaFoldDB; E2NBV5; -.
DR   MEROPS; S26.001; -.
DR   HOGENOM; CLU_028723_1_0_10; -.
DR   Proteomes; UP000003711; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   CDD; cd06530; S26_SPase_I; 2.
DR   Gene3D; 2.10.109.10; Umud Fragment, subunit A; 1.
DR   InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR019533; Peptidase_S26.
DR   NCBIfam; TIGR02227; sigpep_I_bact; 1.
DR   PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR   PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR   Pfam; PF10502; Peptidase_S26; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; LexA/Signal peptidase; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU362042, ECO:0000313|EMBL:EEF90615.1};
KW   Membrane {ECO:0000256|RuleBase:RU362042};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU362042};
KW   Transmembrane {ECO:0000256|RuleBase:RU362042};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362042}.
FT   TRANSMEM        16..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362042"
FT   DOMAIN          22..278
FT                   /note="Peptidase S26"
FT                   /evidence="ECO:0000259|Pfam:PF10502"
FT   ACT_SITE        47
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT   ACT_SITE        121
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ   SEQUENCE   298 AA;  34642 MW;  3CFD2729D2AF9455 CRC64;
     MVVDVKKLIG KCCNRIVNIA FGVCIAIIVF LALQLFFVTS FKIPSDSMEP TLLGGDYILV
     EKCSKGARLF NVIASLEGKK VDIYRMPGWR KFKRNDVLVF NYPYSKRRDS IALDAMVYYV
     KRCVALPGDT LEIRDAHYLV RNCTQPLGNV EGQDFLQSVF ESGKVKEWRI AVRSYPKSKL
     LDWNIGEFGP FYIPAKGSMI KMTPLTKVLY RNVIEWEQDK KLMVREDTVL LGDSIIYQYQ
     FRENYYFVSG DKIENSLDSR YWGLLPEPFI VGRAWRIWKS IDRSTDAVRW DRAFKKIK
//
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