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Database: UniProt
Entry: E2QUL7_CANLF
LinkDB: E2QUL7_CANLF
Original site: E2QUL7_CANLF 
ID   E2QUL7_CANLF            Unreviewed;       946 AA.
AC   E2QUL7;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   25-OCT-2017, entry version 52.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 4 {ECO:0000313|Ensembl:ENSCAFP00000009108};
GN   Name=TRPC4 {ECO:0000313|Ensembl:ENSCAFP00000009108};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000009108, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000009108, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009108,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000009108}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000009108};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000009108}.
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DR   EMBL; AAEX03014201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; E2QUL7; -.
DR   Ensembl; ENSCAFT00000009810; ENSCAFP00000009108; ENSCAFG00000006044.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   TreeFam; TF313147; -.
DR   Reactome; R-CFA-3295583; TRP channels.
DR   Proteomes; UP000002254; Chromosome 25.
DR   Bgee; ENSCAFG00000006044; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005460; TRPC4_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 2.
DR   PANTHER; PTHR10117:SF25; PTHR10117:SF25; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01645; TRPCHANNEL4.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    295    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    370    387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    408    428       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    448    467       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    530    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    564    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   REPEAT      110    142       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   DOMAIN      110    142       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   COILED      196    223       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   946 AA;  108829 MW;  8B3495BDBFAE59F7 CRC64;
     MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK SLEEVELLLS
     FNVYVGDALL HAIRKEVVGA VELLLNHKKP SGEKQVPPIL LDKQFSEFTP DITPIILAAH
     TNNYEIIKLL VQKGVSVPRP HEVRCNCVEC VSSSDVDSLR HSRSRLNIYK ALASPSLIAL
     SSEDPFLTAF QLSWELQELS KVENEFKSEY EELSRQCKQF AKDLLDQTRS SRELEIILNY
     RDDSSLIEEQ SGNDLARLKL AIKYRQKEFV AQPNCQQLLA SRWYDEFPGW RRRHWAVKMV
     TCFIIGLLFP VFSVCYLIAP KSPLGLFIRK PFIKFICHTA SYLTFLFLLL LASQHIDRSD
     LNRQGPPPTI VEWMILPWVL GFIWGEIKQM WDGGLQDYIH DWWNLMDFVM NSLYLATISL
     KIVAFVKYSA LNPRESWDMW HPTLVAEALF AIANIFSSLR LISLFTANSH LGPLQISLGR
     MLLDILKFLF IYCLVLLAFA NGLNQLYFYY EETKGLSCKG IRCEKQNNAF STLFETLQSL
     FWSIFGLINL YVTNVKAQHE FTEFVGATMF GTYNVISLVV LLNMLIAMMN NSYQLIADHA
     DIEWKFARTK LWMSYFEEGG TLPTPFNVIP SPKSLWYLIK WIWTHLCKKK MRRKPESFGT
     IGRRAADNLR RHHQYQEVMR NLVKRYVAAM IRDAKTEEGL TEENFKELKQ DISSFRFEVL
     GLLRGSKFST VQSAQASKEP SNSADSDEKS DNEGSSKDKR KNFSLFDLTT LIHPRSAAIA
     SERHNISNGS ALVVQEPPRE KQRKVNFVTD IKNFGLFHRR SKQNAAEQNA NQIFSVSEEV
     TRQQAERPLE RNIQLESRGL ASRGDLNIPG LSEQCILVDH RERNTDCLGL QVGKRVCSFK
     SEKVVVEDTV PIIPKEKHAK EEDSSIDYDV NLTDTVTHED YVTTRL
//
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