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Database: UniProt
Entry: E2R9S8_CANLF
LinkDB: E2R9S8_CANLF
Original site: E2R9S8_CANLF 
ID   E2R9S8_CANLF            Unreviewed;      1829 AA.
AC   E2R9S8;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   25-OCT-2017, entry version 49.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSCAFP00000001896};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000001896, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000001896, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000001896,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000001896}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000001896};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCAFP00000001896}.
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DR   EMBL; AAEX03007306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03007307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PaxDb; E2R9S8; -.
DR   Ensembl; ENSCAFT00000002048; ENSCAFP00000001896; ENSCAFG00000001314.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000002254; Chromosome 10.
DR   Bgee; ENSCAFG00000001314; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:InterPro.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     13     33       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     54     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    142    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    812    834       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    854    870       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    890    912       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1231   1249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1269   1290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1302   1328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1366   1388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1467   1491       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1547   1564       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1584   1603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1667   1694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1769   1790       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    342       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      690    917       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1229   1501       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1547   1800       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1500   1527       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1829 AA;  204636 MW;  D096500046CEBA2F CRC64;
     SLPDCFVLDS VCTWFECVSM LVILLNCVTL GMYQPCDDMD CLSDRCKILQ VFDDFIFVFF
     AMEMVLKMVA LGIFGKKCYL GDTWNRLDFF IVMAGMVEYS LDLQNINLSA IRTVRVLRPL
     KAINRVPSMR ILVNLLLDTL PMLGNVLLLC FFVFFIFGII GVQLWAGLLR NRCFLEENFT
     IQGDVALPPY YQPEEDDEMP FICSLSGDNG IMGCHEIPPL KEQGRECCLS KDDVYDFGAG
     RQDLNASGLC VNWNRYYNVC RTGSANPHKG AINFDNIGYA WIVIFQVITL EGWVEIMYYV
     MDAHSFYNFI YFILLIIVGS FFMINLCLVV IATQFSETKQ REHRLMLEQR QRYLSSSTVA
     SYAEPGDCYE EIFQYICHIL RKARRRALGL YQALQSRRQA SAPGAPTSTK PGPHAKEPRH
     YTKTSPHSAC LPHHPPHQSS DQPPATWNKG AAAPTLRRHD VSGTPRSWMT QGGAACCCPP
     PCPGNLCGGK PRGPSGLFEM VHRSQNSGPR LAQASQTLPG AAKGMKASAP HSLLSLLSAP
     PGASPNSQLV RARVCPCPGL WPPSLPGTQG PHTELCPQHS PLDPTPHTLV QPISAMLASD
     PASCPRCQHE ESRRPSGPGS TDSGQEGSGS GGSGGGSEEA DGDGARSSED GASSGLGKED
     EEEKADGATR LCGDVWRETR AKLRGIVDSK YFNRGIMMAI LVNTVSMGIE HHEQPEELTN
     ILEICNVVFT SMFALEMLLK LAAFGLFDYL RNPYNIFDSI IVIISIWEIV GQADGGLSVL
     RTFRLLRVLK LVRFMPALRR QLVVLMKTMD NVATFCMLLM LFIFIFSILG MHIFGCKFSL
     RTDTGDTVPD RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL YFVALMTFGN
     YVLFNLLVAI LVEGFQAEQF GREGRAEPTC IPTRGMVSQG DANRSYSDED QSSSNIMEGN
     GQRPQRSKLR ALQEGSSLRL IPRNWVFILA TMLQLPQGKQ AGGRAAGVQA RLPPSQQRAA
     CAVASFQSSS RSSYYGPWGR SGAWASRRSS WNSLKHKPLS AEHESLLSAE RGGGPRACEG
     ARDEGPPRAA PPHAPHAHHV HHGPHAAHRH RHHRRTLSLD TRDSMDLAEL VPAVGAHPRA
     AWRAVGPAPG HEDCNGRMPS IAKDVFTKMD DRRDRGEDEE EIDYTLCFRV RKMIDVYKPD
     WCEVREDWSV YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE
     RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV SIIDIVVSVA
     SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI SSLKPIGNIV LICCAFFIIF
     GILGVQLFKG KFYHCLGVDT RNITNRSDCV AANYRWVHHK YNFDNLGQAL MSLFVLASKD
     GWVNIMYNGL DAVAVDQQPV PNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH
     QEAEEARRRE EKRLRRLEKK RRKAQRLPYY ATYCPTRLLI HSMCTSHYLD IFITFIICLN
     VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR WNQLDLAIVL
     LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK MATGMRALLD TVVQALPQVG
     NLGLLFMLLF FIYAALGVEL FGKLVCNDEN PCEGMSRHAT FENFGMAFLT LFQVSTGDNW
     NGIMKDTLRD CTHDERSCLS SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA
     QEDAEMDAEL ELEMAHGLGP SPRPPSSSP
//
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