ID E2RTN4_GIAIC Unreviewed; 251 AA.
AC E2RTN4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Ribosomal protein L2 {ECO:0000313|EMBL:EDO76580.1};
DE SubName: Full=Ribosomal protein L8 {ECO:0000313|EMBL:KAE8304822.1};
GN ORFNames=GL50803_0016086 {ECO:0000313|EMBL:KAE8304822.1},
GN GL50803_16086 {ECO:0000313|EMBL:EDO76580.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO76580.1};
RN [1] {ECO:0000313|EMBL:EDO76580.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO76580.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304822.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304822.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:7PWG, ECO:0007829|PDB:7PWO}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.75 ANGSTROMS).
RX PubMed=35100413; DOI=10.1093/nar/gkac046;
RA Hiregange D.G., Rivalta A., Bose T., Breiner-Goldstein E., Samiya S.,
RA Cimicata G., Kulakova L., Zimmerman E., Bashan A., Herzberg O., Yonath A.;
RT "Cryo-EM structure of the ancient eukaryotic ribosome from the human
RT parasite Giardia lamblia.";
RL Nucleic Acids Res. 50:1770-1782(2022).
RN [4] {ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.25 ANGSTROMS).
RX PubMed=36912103; DOI=10.1093/nar/gkad176;
RA Majumdar S., Emmerich A., Krakovka S., Mandava C.S., Svard S.G., Sanyal S.;
RT "Insights into translocation mechanism and ribosome evolution from cryo-EM
RT structures of translocation intermediates of Giardia intestinalis. .";
RL Nucleic Acids Res. 51:3436-3451(2023).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC {ECO:0000256|ARBA:ARBA00005636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO76580.1}.
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DR EMBL; AACB02000062; EDO76580.1; -; Genomic_DNA.
DR EMBL; AACB03000001; KAE8304822.1; -; Genomic_DNA.
DR RefSeq; XP_001704254.1; XM_001704202.1.
DR PDB; 7PWG; EM; 2.75 A; A=1-251.
DR PDB; 7PWO; EM; 2.75 A; A2=1-251.
DR PDB; 8BR8; EM; 3.35 A; LA=1-251.
DR PDB; 8BRM; EM; 3.33 A; LA=1-251.
DR PDB; 8BSI; EM; 3.40 A; LA=1-251.
DR PDB; 8BSJ; EM; 6.49 A; LA=1-251.
DR PDB; 8BTD; EM; 4.90 A; LA=1-251.
DR PDB; 8BTR; EM; 3.25 A; LA=1-251.
DR EMDB; EMD-13681; -.
DR EMDB; EMD-13683; -.
DR SMR; E2RTN4; -.
DR STRING; 184922.E2RTN4; -.
DR EnsemblProtists; EDO76580; EDO76580; GL50803_16086.
DR GeneID; 5697104; -.
DR KEGG; gla:GL50803_0016086; -.
DR VEuPathDB; GiardiaDB:GL50803_16086; -.
DR HOGENOM; CLU_036235_0_3_1; -.
DR OMA; GGRHPCT; -.
DR Proteomes; UP000001548; Chromosome 5.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 4.10.950.10; Ribosomal protein L2, domain 3; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR002171; Ribosomal_uL2.
DR InterPro; IPR022669; Ribosomal_uL2_C.
DR InterPro; IPR022671; Ribosomal_uL2_CS.
DR InterPro; IPR014726; Ribosomal_uL2_dom3.
DR InterPro; IPR022666; Ribosomal_uL2_RNA-bd_dom.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR13691:SF16; 60S RIBOSOMAL PROTEIN L8; 1.
DR PANTHER; PTHR13691; RIBOSOMAL PROTEIN L2; 1.
DR Pfam; PF00181; Ribosomal_L2; 1.
DR Pfam; PF03947; Ribosomal_L2_C; 1.
DR PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR SMART; SM01383; Ribosomal_L2; 1.
DR SMART; SM01382; Ribosomal_L2_C; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7PWG, ECO:0007829|PDB:7PWO};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000313|EMBL:EDO76580.1}.
FT DOMAIN 96..231
FT /note="Large ribosomal subunit protein uL2 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01382"
SQ SEQUENCE 251 AA; 27037 MW; 90C56CB321DF00E8 CRC64;
MGRRIRVQRK GAGSVFRAHV ARRLGAAKLR ANDFAERTGS VRGVVKAILH DRGRGAPLAR
VQFPNMRGEG RVNELFIAPE GMYTGQEVFS GNKATLHIGN ILPVGNIPEG TYVCNVEEKP
MDRGCLARAS GTYCLVVAHN METNKTRIRL PSGQKKLISS KARAMIGLVA GGGRTDKPLL
KAGNAYHKYK AKRNCWPVVR GVAMNPVDHP HGGGNHQHIG VSSCVPRNAV PGQKVGLIAA
RRTGCSGGKR R
//
